Polymeric Gene Delivery Principles and Applications

Written by prominent and international researchers directly involved in the area of polymeric vectors for gene delivery Polymeric Gene Delivery: Principles and Applications is the first comprehensive book to specifically address polymeric gene delivery systems. The book is divided into five sections that deal with challenges and opportunities in gene delivery and the efficient delivery of genes into somatic cells using polymeric vectors. The authors discuss using biodegradable polymers, condensing and non-condensing polymeric systems, microspheres and nanospheres, and designing specialized delivery systems based on targeting strategies. This book is an up-to-date guide for researchers in the field and those interested in entering this dynamic field.

To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry, and limited scale of industrial production.Polymeric Gene Delivery: Principles and Applications is the first comprehensive book to specifically address polymeric gene delivery systems. Uniting the expertise of international academic and industrial scientists who are working in the area of polymeric vectors for gene delivery, it is written by prominent researchers directly involved in this field. The book is divided into five sections that deal with challenges and opportunities in gene delivery and the efficient delivery of genes into somatic cells using polymeric vectors. The authors discuss using biodegradable polymers, condensing and non-condensing polymeric systems, microspheres and nanospheres, and designing specialized delivery systems based on targeting strategies.Polymeric Gene Delivery: Principles and Applications accentuates the versatility of polymeric delivery systems, including the potential for biocompatibility, the ability to design their formulation and geometry for a specific purpose, and the ease of modification to the surface of polymeric carriers. This book is an up-to-date guide for researchers in the field and those interested in entering this dynamic field.

Introduction; Robert Langer, MIT, Cambridge, MAGENE DELIVERY: CHALLENGES AND OPPORTUNITIESTissue and Cell Specific Targeting for the Delivery of Genetic Information; Randall J. Mrsny, University of Wales, UKBiological Barriers to Gene Transfer; Yasufumi Kaneda, Osaka University, JapanCellular Uptake and Trafficking; Sujatha Dokka and Yon Rojanasakul, West Virginia University. Morgantown, WV, USAPharmacokinetics of Polymer/Plasmid DNA Complex; Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida, Kyoto University, JapanCONDENSING POLYMERIC SYSTEMSA. Non-Degradable PolymersPoly(L-Lysine) and Copolymers for Gene Delivery; Minhyung Lee and Sung Wan Kim, University of Utah, Salt Lake City, USAGene Delivery Using Polyethyleneimine and Copolymers; Manfred Ogris, Centre of Drug Research, LMU Munich, GermanyChapter 8. Poly(2-(Dimethylamino)Ethyl Methacrylate)-Based Polymers for the Delivery of Genes In Vitro and In Vivo; .J. Verbaan, D.J.A. Crommelin, W.E. Hennink, and G. Storm, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The NetherlandsCationic Dendrimers as Gene Transfection Vectors; Lori A. Kubasiak and Donald A. Tomalia, Dendritic Nanotechnologies, Inc., Mt. Pleasant, MIPoly(ethylene glycol)-Conjugated Cationic Dendrimers; Joon Sig Choi, Tae-il Kim, and Jong-Sang Park, Seoul National University, KoreaWater Soluble Lipopolymers for Gene Delivery; Ram I. Mahato, University of Tennessee Health Science Center, Memphis, and Sung Wan Kim, University of Utah, Salt Lake City, USACyclodextrin-Containing Polymers for Gene Delivery; Suzie Hwang Pun, Insert Therapeutics, Pasadena, CA, and Mark E. Davis, California Institute of Technology, Pasadena, CA, USAB. Biodegradable PolymersGene Delivery Using Polyimidazoles and Related Polymers; Sharon Wong and David Putnam, Cornell University, Ithaca, NY, USAPoly(?-amino ester)s for Gene Delivery; David M. Lynn, University of Wisconsin, Madison, WI, and Daniel G. Anderson, Akin Akinc, and Robert Langer, Massachusetts Institute of Technology, Cambridge, MA, USACationic Polyesters as Biodegradable Gene Delivery Carriers; Yong-beom Lim, Yan Lee, and Jong-Sang Park, Seoul National University, KoreaPoly(amidoamine)s for Gene Delivery; Paolo Ferruti and Jacopo Franchini, University of Milan, ItalyChapter 17. Cationic Polysaccharides for Gene Delivery; Tony Azzam and Abraham J. Domb, The Hebrew University - Hadassah Medical School, Jerusalem, IsraelChitosan Complexes; Gerrit Borchard and Maytal Bivas-Benita, Leiden University, The Netherlands NON-CONDENSING POLYMERIC SYSTEMSPluronic® Block Copolymers for Non-Viral Gene Delivery; Alexander V. Kabanov and Srikanth Sriadibhatla, University of Nebraska Medical Center, Omaha, NE, and Valery Yu. Alakhov, Supratek Pharma, Inc., Dorval, Quebec, CanadaUse of Poly(N-vinyl pyrrolidone) with Noncondensed Plasmid DNA Formulations for Gene Therapy and Vaccines; Michael Nicolaou and Mark Newman, Epimmune, Inc., San Diego, CA, Polly Chang, SRI International, Menlo Park, CA, USAUse of HPMA Copolymers for Gene Delivery; David Oupicky, Wayne State University, Detroit, MI, USAPOLYMERIC NANOSPHERES AND MICROSPHERESA. Polymeric NanospheresBiodegradable Nanoparticles as Gene Expression Vector; Swayam Prabha, Wenxue Ma, and Vinod Labhasetwar, University of Nebraska Medical Center, Omaha, USANanoparticles Made of Poly(lactic acid) and Poly(ethylene oxide) as Carriers of Plasmid DNA; Noemi Csaba, Celso Perez, Alejandro Sanchez, and Maria Jose Alonso, University of Santiago de Compostela, SpainPoly(alkylcyanoacrylate) Nanoparticles for Nucleic Acid Delivery; Elias Fattal and Patrick Couvreur, University of Paris-Sud, FranceLayer-by-Layer Nanoengineering with Polyelectrolytes for Bioactive Compound Delivery Applications; Dinesh B. Shenoy, Alexei A. Antipov, and Gleb B. Sukhorukov, Max-Planck Institute of Colloids and Interfaces, Potsdam/Golm, GermanyEx Vivo and In Vivo Adenovirus-Mediated Gene Delivery intro Refractory Cells via Nanoparticle Hydrogel Formulation; Ales Prokop and Gianluca Carlesso, Vanderbilt University, Nashville, TN, and Jeffrey M. Davidson, Department of Veteran Affairs Medical Center, Nashville, TN, USAProtein Nanoparticles for Gene Delivery; Goldie Kaul and Mansoor Amiji, Northeastern University, Boston, MA, USAB. Polymeric MicrospheresGene Delivery Using Poly(lactide-co-glycolide) Microspheres; Mary Lynne Hedley; Zycos, Inc.; Lexington, MA, USAPolyanhydride Microspheres for Gene Delivery; Yong S Jong and Camilla A Santos, Spherics Inc., Lincoln, RI, and Edith Mathiowitz, Brown University, Providence, RI, USAMicrospheres Formulated with Native Hyaluronan for Applications in Gene Therapy; Yang H. Yun and Weiliam Chen, State University of New York at Stony Brook, Stony Brook, NY, USASPECIALIZED DELIVERY SYSTEMSGenetically Engineered Protein-Based Polymers: Potential in Gene Delivery; Zaki Mageed and Hamid Ghandehari, University of Maryland, Baltimore, MD, USAGlycopolymer Tools for Studying Targeted Non-Viral Gene Delivery; Kevin G. Rice, Je-Seon Kim, and Dijie Liu, University of Iowa, Iowa City, USATargeted Gene Delivery via the Folate Receptor; Shih-Jiuan Chiu and Robert J. Lee, Ohio State University, Columbus, USATransferrin Receptor-Targeted Gene Delivery Systems; Ralf Kircheis, Igeneon Immunotherapy of Cancer, Vienna, Austria, and Ernst Wagner, Pharmaceutical Biology/Biotechnology, Ludwig-Maximilians University, Munich, GermanyGene Delivery to the Lungs; Berma M. Kinsey, Charles L. Densmore, and Frank M. Orson, Baylor College of Medicine, Houston, TX, USACutaneous Gene Delivery; James C. Birchall, Cardiff University, Wales, UKEnhancement of Wound Repair by Sustained Gene Transfer via Hyaluronan Matrices; Angela Kim, Daniel M. Checkla, Don Wen, Philip Dehazya, and Weiliam Chen1, Clear Solutions Biotech, Inc., Stony Brook, NY, and 1State University of New York at Stony Brook, NY, USAGene Delivery from Tissue Engineering Matrices; Zain Bengali, Christopher B. Rives, and Lonnie D. Shea, Northwestern University, Evanston, IL, USAGene Therapy Stents for Instent Restenosis; Ilia Fishbein, Itay Perlstein, and Robert Levy, University of Pennsylvania Medical Center and Children's Hospital of Philadelphia, PA USAGene Delivery Using BioMEMS; Krishnendu Roy, University of Texas, Austin, USA