Polymeric Biomaterials for Tissue Regeneration From Surface/Interface Design to 3D Constructs

This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies.

In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.

Chapter 1. An Introduction to Scaffolds, Biomaterial Surfaces, and Stem Cells.- Part I. Structural Scaffolds and Bio-activation.- Chapter 2. Polymeric and Biomimetic ECM Scaffolds for Tissue Engineering Applications.- Chapter 3. Versatile Hydrogels in Regenerative Medicine.- Chapter 4. Multilayer Microcapsules with Tailored Structures and Properties as Delivery Carriers for Drugs and Growth Factors.- Part II Biomaterials Surfaces/Interfaces and Bio-interactions. Chapter 5. Interactions of Biomaterial Surfaces with Proteins and Cells.- Chapter 6. Surface Modification of Tissue Engineering Scaffolds.- Chapter 7. Gradient Biomaterials and Their Impact on Cell Migration.- Chapter 8. Stem Cell Differentiation Mediated by Biomaterials/Surfaces.- Part III Regeneration of Some Clinic-Targeted Tissues.- Chapter 9. Cartilage Regeneration.- Chapter 10. Skin Regeneration.- Chapter 11. Regeneration of Blood Vessels.- Chapter 12. Cardiac repair and regeneration.- Chapter 13.Nerve Regeneration.

Dr. Changyou Gao is a distinguished professor of Department of Polymer Science and Engineering, Zhejiang University. He is a Cheung Kong Scholar of Ministry of Education of China, a winner of the National Science Fund for Distinguished Young Scholars of China, a fellow of the International Federation of Biomaterial Science and Engineering Societies, a fellow of the American Academy of Medicine and Biological Engineering, a fellow of Royal Society of Chemistry, and a highly cited scientist in Materials Science over the last years (Elsevier). He is now serving as an associate president of Chinese Society of Biomaterials, an associate editor of Biomaterials Advances (original name: Materials Science & Engineering C), and an editorial member of ACS Biomaterials Science and Engineering, Colloids and Surfaces B: Biointerfaces, Regenerative Biomaterials, and Chinese Journal of Polymer Science, among others. His research interests include stimuli-responsive biomedical polymers and colloids/microparticles as well as their applications in the therapy of myocardium infarction, osteoarthritis, and peripheral and central nerve defects. He has published more than 500 papers with a citation over 13,000 times by peers and an H-index of 76. He has edited 4 books as a chief editor and contributed over 10 chapters.