Polymer Biomaterials in Solution, as Interfaces and as Solids A Festschrift Honoring the 60th Birthday of Dr. Allan S. Hoffman

The articles collected in this publication have previously been published in eight special issues of the Journal of Biomaterials Science, Polymer Edition, in honour of Dr. Allan S. Hoffman, who is known as a pioneer, a leader and a mentor in the field of biomaterials. The papers from renowned scientists from all parts of the world, representing the state-of-the-art in polymeric biomaterials today, have been rearranged into a logical order of sections, each having a distinct focus. The topics covered are: Surface Modification, Characterization and Properties; Protein Adsorption; Blood Interactions; Cell Interactions; Immobilized Cell Receptor Ligands and Immobilized Cells; Immobilized Biomolecules and Synthetic Derivatives of Biomolecules; New Polymers and Applications; Biodegradable Polymers and Drug Delivery; Water-Soluble Biomolecules, Sunthetic Polymers, and their Conjugates; Hydrogels.

Part I: Surface Modification, Characterization, and Properties Part IA: RF Plasma Gas Discharge 1. Molecular surface tailoring of biomaterials via pulsed RF plasma discharges 2. Introduction of amine groups on poly(ethylene) by plasma immobilization of a preadsorbed layer of decylamine hydrochloride 3. A wettability gradient as a tool to study protein adsorption and cell adhesion on polymer surfaces 4. Activity of horseradish peroxide adsorbed on radio frequency glow discharge-treated polymers 5. Patterned neuronal attachment and outgrowth on surface modified, electrically charged fluoropolymer substrates Part IB: Physico-Chemical Modification 6. New biomaterials through surface segregation phenomenon: New quaternary ammonium compounds as antibacterial agents 7. Biomaterials with permanent hydrophilic surfaces and low protein adsorption properties 8. Surface properties of RGD-peptide grafted polyurethane block copolymers: Variable take-off angle and cold-stage ESCA studies 9. Effect of polyurethane surface chemistry on its lipid sorption behavior Part II: Protein Adsorption 10. Residence time effects on monoclonal antibody binding to adsorbed fibrinogen 11. Adsorption behavior of fibrinogen to sulfonated polyethyleneoxide-grafted polyurethane surfaces 12. Effects of branching and molecular weight of surface-bound poly(ethylene oxide) on protein rejection 13. Review Formation of protein multilayers and their competitive replacement based on self-assembled biotinylated phospholipids 14. Identification of proteins adsorbed to hemodialyser membranes from heparinized plasma Part III: Blood Interactions 15. Mechanism of cytoplasmic calcium changes in platelets in contact with polystyrene and poly(acrylamide-co-methacrylic acid) surfaces 16. The synthesis of a water soluble complement activating polyacrylic acid-IgG polymer 17. A novel biomaterial: Poly(dimethylsiloxane)-polyamide multiblock copolymer I. Synthesis and evaluation of blood compatibility 18. Synthesis and non

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