Phospholipid-Binding Antibodies

First published in 1991. Historically, phospholipid binding antibodies were important in the study of syphilis. During the 1980s there was a resurgence of new interest in these antibodies due to reported associations with recurrent thrombosis, fetal loss, and other clinical disorders. Because of the variety of reported clinical associations and their occurrence in systemic autoimmune disorders, these antibodies have become important in many medical fields, such as clinical immunology, rheumatology, hematology, and obstetrics and gynecology. Phospholipid-Binding Antibodies provides in-depth reviews by specialists in these clinical areas and covers topics including the biochemistry of phospholipids, their role in coagulation, phospholipid immunology, and lupus anticoagulant and antiphospholipid antibodies by solid phase immunoassays. Other topics include thrombosis and fetal loss, as well as the role of phospholipid binding antibodies in these disorders. Antiphospholipid Syndrome and its reported clinical associations is also discussed.

SECTION I: PHOSPHOLIPIDS AND CLOTTING. Structures and Properties of Self-Assembled Phospholipids in Excess Water (Ching-Hsien Huang). Phospholipids and the Clotting Process (Robert F.A. Zwaall, Edouard M. Bevers, Jan Rosing). SECTION II: THE IMMUNOLOGY OF PHOSPHOLIPID BINDING AUTOANTIBODIES. Autoantibodies: Their Nature and Significance (Keith B. Elkon). Antibodies to Lipids and Lipid Membranes: Reactions with Phosphatidyl-Choline, Cholesterol, Liposomes, and Bromolin-Treated Erythromytes (Carl R. Alving). Phospholipid Binding Antibodies in Natural and Experimental Syphilis (Konrad Wicher, Victoria Wicher). Role of Monoclonal Antibodies in Understanding the Interactions Between Anti-Phospholipid Antibodies and Phospholipids (Joyce Rauch, Andrew S. Janoff). The Immunology of Phospholipid Binding Antibodies in the Anti-Phospholipid Syndrome and Related Disorders (E. Nigel Harris, Genesio Balestrieri, Angela Tincani, Azzudin E. Gharavi). SECTION III: MEASUREMENT OF PHOSPHOLIPID BINDING ANTIBODIES. Lupus Anticoagulants: Characteristics, Methods of Laboratory Detection and Some Clinical Associations (Thomas Exner, Douglas Triplett). Acquired Circulating Anticoagulants Other Than Lupus Anticoagulants (Thomas Exner, David Green). The Anti-Cardiolipin Assay (E. Nigel Harris, Azzudin E. Gharavi, Graham R.V. Hughes). SECTION IV: PHOSPHOLIPID BINDING ANTIBODIES AND THROMBOSIS. Arterial Thrombosis: Diagnosis and Management (H. Patrick McNeil, Steven A. Krilis, Colin Chesterman). Spontaneous (Unexplained) Thrombosis: The Inherited Basis for the Thrombohemorrhagic Balance (Helge Stormorken). The Pathogenic Role of Anti-Phospholipid Antibodies in Thrombosis (Ronald H. Derksen, Paula Hasselaar, Ph.G. DeGroot). Anti-Phospholipid Antibodies and Impairment of Prostacyclin Synthesis by Endothelium (Luis O. Carreras, Jos Vermylen). Anti-Phospholipid Autoantibodies in Thrombosis: Cause and/or Consequence of the Rupture of the Protein C-Dependent Hemostatic Balance (Jean-Marie Freyssinet, Catherine Ravanat, Lelia Grunebaum, Marie Louise Wiesel, Jean Pierre Cazenave). SECTION V: PHOSPHOLIPID BINDING ANTIBODIES AND PREGNANCY LOSS. Habitual Abortion (Dwight D. Pridham, Christine L. Cook). Pregnancy in SLE (Michael D. Lockshin). Treatment of Anti-Phospholipid Antibody Mediated Fetal Loss: The Case for Corticosteroid Therapy (Neil S. Pattison, Wilhelm F. Lubbe). Clinical Implication of Anti-Phospholipid Antibodies: The Utah Experience (Ware D. Branch, James R. Scott). Alternative Approaches to Treatment of Women with Anti-Phospholipid Antibodies and Fetal Loss (Susan F. Cowchock). Anti-Phospholipid Antibodies and Fetal Loss-Proposed Mechanism (Neil A. MacLachland, Murdo G. Elder). SECTION VI: THE ANTI-PHOSPHOLIPID SYNDROME. The "Anti-Phospholipid Syndrome" - An Introduction (E.Nigel Harris). The "PRIMARY" Anti-Phospholipid Syndrome (Ronald A. Asherson). Anti-Phospholipid Antibodies: Clinical Complications Reported in the Literature (Ronald A. Asherson). Hematological Immune Cytopenias and Anti-Phospholipid Antibodies (Munther A. Khamashta, Samuel J. Machin). Anti-Phospholipid Syndrome in Murine Lupus (Azzudin E. Gharavi). Anti-Phospholipid Antibodies: A Personal History (Graham R.V. Hughes).

E. Nigel Harris, Thomas Exner, Graham R. V. Hughes, Ronald A. Asherson