Pain and Neurogenic Inflammation

This volume is intended to bring together recent advances in the often separate fields of pain and neurogenic inflammation. To this end, eminent researchers from both domains have contributed in-depth discussion of the mechanisms underlying these processes. Individual chapters focus on important recent discoveries such as the cloning of the capsaicin receptor and the discovery of RAMP proteins for CGRP receptors. This book provides an integrated account of recent advances in the fields of pain and neurogenic inflammation. The volume is intended to bring together studies from eminent researchers in the often separate research fields of pain and inflammation. "Pain and Neurogenic Inflammation" is aimed primarily at postgraduate researchers as well as academic and industrial researchers in pain and inflammation but is also likely to be of interest to undergraduate students seeking a firm grounding in the mechanisms underlying these important clinical conditions.

A comparative discussion of A? and C fibres in different tissues.- The roles of spinal receptors in nociceptive responses.- Cutaneous hyperalgesia.- Capsaicin and pain mechanisms.- Nitric oxide and inflammatory pain.- Interactions between kinins and the inflammatory pain process.- Sensory neuropeptides, neurogenic inflammation and inflammatory cells.- Inflammatory pain and the joint.- Nerve growth factor and sensory nerve function.- The relationship between hyperalgesia and hyperresponsiveness in the lung.- Neuropeptides and the respiratory tract: Relevance to asthma and rhinitis.- Neuropeptides and the gut: Tachykinins and calcitonin gene-related peptide in intestinal inflammation and pain.- Regulation of meningeal blood flow by neuropeptides: Relevance to migraine.- Sensory peptides: Effects in ageing and wound healing.- Calcitonin gene-related peptides and their receptors.- Tachykinin receptors and the potential of tachykinin antagonists as clinically effective analgesics and anti-inflammatory agents.