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scott david l. (curatore); galloway james (curatore); cope andrew (curatore); pratt arthur (curatore); strand vibeke (curatore) - oxford textbook of rheumatoid arthritis
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Oxford Textbook of Rheumatoid Arthritis

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Dettagli

Genere:Libro
Lingua: Inglese
Pubblicazione: 09/2020





Note Editore

This brand new textbook of rheumatoid arthritis (RA) is an important addition to the Oxford Textbooks in Rheumatology series, and provides a comprehensive overview of both the scientific and clinical aspects of the disease. Divided into eight sections - from the history, diagnosis, and epidemiology of the disease, through the pathogenesis, clinical presentation, and assessment to treatments and management strategies, both drug- and non-drug based - each chapter is written by leading clinicians and scientists in the field to deliver a contemporary view of RA. During the past two decades there have been revolutionary changes in the understanding and management of rheumatoid arthritis, in particular the development of biological treatments. This has had wide-ranging effects on almost all aspects of treatment, from effectiveness and intensity to the nature and the cost. Providing a comprehensive account of the modern ideas about the disease, the Oxford Textbook of Rheumatoid Arthritis is a key new addition to the literature, with each chapter providing a detailed background, key recent advances, and areas of doubt and future developments. Featuring over 170 photographs, radiological images, and clinical charts to aid both diagnosis and illustrate the rationale behind key scientific studies, this new title will prove an indispensable resource for specialist rheumatologists, trainees in rheumatology, and other members of the multi-disciplinary team.




Sommario

1 - The history of rheumatoid arthritis
2 - Diagnosis
3 - The descriptive epidemiology of rheumatoid arthritis
4 - Modifiable and other risk factors for rheumatoid arthritis: a basis for prevention and better therapy
5 - Genetics and epigenetics of rheumatoid arthritis
6 - Dysregulation of synovial fibroblasts in rheumatoid arthritis
7 - Autoantibodies in rheumatoid arthritis
8 - Dendritic cells and T cells in rheumatoid arthritis
9 - Mechanisms of bone and cartilage destruction
10 - Cytokines and other mediators
11 - Clinical features of rheumatoid arthritis
12 - Pre-rheumatoid arthritis
13 - Non-articular manifestations of rheumatoid arthritis
14 - Comorbidity in rheumatoid arthritis
15 - Disease activity assessment in rheumatoid arthritis
16 - Synovial biopsies
17 - Radiography in rheumatoid arthritis
18 - Ultrasound in rheumatoid arthritis
19 - MRI in rheumatoid arthritis
20 - Patient physical function in rheumatoid arthritis
21 - Fatigue
22 - Health economics
23 - Rheumatoid arthritis and work
24 - Exercise
25 - Foot health
26 - Occupational therapy
27 - Self-management: a patient's perspective
28 - Analgesics, Opioids, and NSAIDs
29 - Glucocorticoids
30 - Conventional disease modifying drugs
31 - Tumour necrosis factor inhibitors
32 - Interleukin-6 inhibitors
33 - B-cell therapies
34 - Biosimilars
35 - Immunogenicity in response to biologic agents
36 - The use of JAK inhibitors in the treatment of rheumatoid arthritis
37 - Combination therapy in rheumatoid arthritis
38 - Translation of new therapies: from bench to bedside
39 - Adverse events in clinical studies in rheumatoid arthritis
40 - Prevention of rheumatoid arthritis
41 - Treatment targets and remission
42 - Clinical outcomes
43 - Clinical guidelines
44 - European biologics registers
45 - Voluntary patient registries




Autore

David L. Scott is Professor of Clinical Rheumatology at King's College London. He trained in medicine and rheumatology in Leeds and Birmingham and subsequently held a fellowship at St Bartholomew's Hospital in London. His current academic focus spans the outcomes of rheumatoid arthritis and the impact of intensive treatment in improving outcomes in clinical trials. James Galloway is Senior Lecturer in Rheumatology at King's College London and Honorary Consultant Rheumatologist at King's College Hospital. After training in medicine and rheumatology in Bristol and Manchester he held a fellowship at the Arthritis Research UK Epidemiology Unit in Manchester. His current academic focus is on large observational studies of arthritis and treatment risks including infections Andrew Cope is Arthritis Research UK Professor of Rheumatology at King's College London and Honorary Consultant Rheumatologist at Guy's and St Thomas's Hospital. After training in medicine and rheumatology in London he held fellowships at the Kennedy Institute of Rheumatology and Stanford University. His current academic focus spans laboratory studies, clinical trials and observational studies with an emphasis on understanding the immunobiology of inflammatory arthritis. Arthur Pratt is Clinical Fellow in the Institute of Cellular Medicine and Honorary Consultant Rheumatologist at the Freeman Hospital in Newcastle. He trained in medicine and rheumatology in Leeds and Newcastle. Subsequently he was a training fellow and National Institute for Health Clinical Lecturer at Newcastle University. His current academic focus is clinical and laboratory assessments and predictors in early inflammatory arthritis. Vibeke Strand is Adjunct Clinical Professor, in the Division of Immunology and Rheumatology at Stanford University. She is a clinical rheumatologist and acts as a consultant in biopharmaceutics, clinical research, and regulatory affairs to many pharmaceutical and biotech companies. After graduating from Swarthmore College she trained in medicine and rheumatology at University of California San Francisco School of Medicine. Her current academic focus spans clinical trial design, development of outcome measures with an emphasis on patient reported outcomes and regulatory strategies leading to approval of new agents for treatment of autoimmune diseases. She gives particular emphasis to translating basic research findings into rationally designed clinical trials, evaluating their results and helping patients access new treatments.










Altre Informazioni

ISBN:

9780198831433

Condizione: Nuovo
Dimensioni: 284 x 28.0 x 228 mm Ø 1658 gr
Formato: Copertina rigida
Pagine Arabe: 576


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