Nutrigenomics How Science Works

Now in its second edition, this concise textbook provides an overview of the field of nutrigenomics, a topic at the intersection of nutrition and genetics that explores how dietary molecules interact with our genome and epigenome to influence health and disease. Substantially updated and expanded, the book offers a fresh perspective on how diet has shaped human evolution and our susceptibility to conditions such as type 2 diabetes and cardiovascular disease.

The 11 chapters cover a wide range of topics, beginning with an overview of the role of nutrients in health and disease, basic mechanisms of nutrient sensing and nuclear receptors, and the impact of epigenetic regulation on health. Readers will discover how chromatin-modifying enzymes and energy status-sensing kinases play critical roles in signaling pathways between diet and the genome. The book also explores the influence of diet on cancer prevention, the importance of the microbiome, and low-grade chronic inflammation and aging. 

Written in an accessible style, this textbook is intended for undergraduate and graduate students in nutrition, biochemistry, molecular biology, and biology as well as for students and practitioners in medicine. Numerous color illustrations aid in the transfer of knowledge by graphically summarizing complex processes. Combined with a glossary that explains key terms, this work is an indispensable resource for anyone interested in how our daily dietary choices interact with our genome.

Nutrition's Role in Health and Disease.- Diet Driven Genetic Adaptations of Modern Humans.- Mechanisms of Nutrient Detection and Nuclear Receptors.- Interplay Between Environment, Diet, and Genome.- Nutritional Epigenetics.- Nutrition and Aging.- Nutrition and Immune Responses.- Nutrition and Cancer.- Obesity.- Insulin Resistance and Diabetes.- CVD and Metabolic Syndrome.

Carsten Carlberg graduated in 1989 with a PhD in biochemistry at the Free University Berlin (Germany). After positions as Postdoc at Roche (Basel, Switzerland), Group Leader at the University of Geneva (Switzerland), and Docent at the University of Düsseldorf (Germany), he is since 2000 Full Professor of biochemistry at the University of Eastern Finland in Kuopio (Finland). Since 2022, Prof. Carlberg is ERA Chair for nutrigenomics at the Polish Academy of Sciences in Olsztyn (Poland). His work focuses on mechanisms of gene regulation by vitamin D, in particular on epigenome-wide effects of vitamin D on the human immune system in healthy and diseased individuals.
 
Ferdinand Molnár received his PhD in biochemistry from the University of Kuopio (Kuopio, Finland) in 2006. He did his postdoctoral training in Structural Biology at the IGBMC (Illkirch, France). In 2008 he joined the School of Pharmacy at the University of Eastern Finland (Kuopio, Finland) studying nuclear receptor-ligand, - protein and -DNA interactions. In 2018 he moved to the Nazarbayev University (Nur-Sultan, Kazakhstan) where he holds an Associate Professor position at the Department of Biology. Prof. Molnár interests are integrative structural biology and bioinformatics, eukaryotic transcriptional regulation in health and disease and recombinant protein production.