Neuroprogression in Psychiatry

Recent studies regarding the neuropathology of specific neurological disorders suggest that both neurodevelopmental and neurodegenerative processes may play a role. However, in contrast to the neurodegeneration seen in neurological disorders such as Parkinson's and Alzheimer's disease, the term "neuroprogression" has been used to describe the neurodevelopmental aspect of pathological brain re-wiring that takes place in the context of severe psychiatric disorders, such as schizophrenia or bipolar disorder. Within psychiatry, patients with severe psychopathology, such as those depressed patients who eventually commit suicide, have been shown to present with increased inflammatory markers in the brain. A similar increase in inflammatory markers is also found in patients with bipolar disorders and schizophrenia. Thus, oxidative stress, inflammation, and changes in growth factors are thought to be the pathways of neuroprogression. Neuroprogression in Psychiatry provides a comprehensive summary of the current developments in the emerging field of neuroprogression. With contributions by leading researchers in the field, this book examines the role of neuroprogression across a wide range of specific psychiatric disorders, with chapters included on major depressive disorder, anxiety disorder, post-traumatic stress disorder, substance abuse, schizophrenia, and bipolar disorder.

1 - A short introductory note on neuroprogression and staging in psychiatry
2 - Allostasis and neuroprogression in major psychiatric disorders
3 - Neuroprogression and accelerated aging in severe psychiatric disorders
4 - Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders
5 - The role of immuno-inflammatory abnormalities in neuroprogression
6 - Depression and neuroprogression: Sirtuins and mitochondria as crucial hubs
7 - Neuroprogression in post-traumatic stress disorder
8 - Neuroprogression in anxiety disorders
9 - Functioning and illness progression in severe mental illness
10 - Neuropsychological functioning and neuroimaging in bipolar disorder: Evidence of neuroprogression
11 - Neuroprogression in children and adolescents with bipolar disorder
12 - Substance abuse and neuroprogression
13 - Lifestyle and neuroprogression: Diet, sleep, and exercise
14 - The pernicious procession of somatoprogression

Flávio Kapczinski is a Professor in the Department of Psychiatry and Behavioural Neurosciences, and the Director of the Graduate Program in Neuroscience at McMaster University, Hamilton, ON, Canada. Michael Berk is the Alfred Deakin Chair of Psychiatry in the School of Medicine, Deakin University, Geelong, VIC, Australia. He is also the NHMRC Senior Principal Research Fellow in the Department of Psychiatry at the University of Melbourne, Parkville, VIC, Australia, as well as an Honorary Professorial Research Fellow at the Florey Institute for Neuroscience and Mental Health and Orygen Youth Health, University of Melbourne, Parkville, VIC, Australia. Pedro Vieira da Silva Magalhães is an Adjunct Professor in the Department of Psychiatry and Legal Medicine, and a Professor for the Postgraduate Program in Psychiatry and Behavioral Sciences, at the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.