Neuropeptide Function in the Gastrointestinal Tract

First published in 1991: This book assimilates and evaluates the rapidly accumulating information regarding neuropeptides in the gut, their chemistry; genetic control; processing in enteric nerves; the projections of their nerves; their actions at the tissue, cell, and molecular levels; and their roles in controlling gut motility in health and disease. Neuropeptide Function in the Gastrointestinal Tract is directed to scientists in all disciplines who work with neuropeptides, as well as physiologists interested in the neural and smooth muscle actions of neuropeptides.

1. A Historical Overview of the Gastroenteropancreatic Regulatory Peptides T.J. McDonald 2. Gastroenteropancreatic Regulatory Peptides Structures: An Overview T.J. McDonald 3. Regulation of Gastrointestinal Neuropeptide Gene Expression and Processing Ake Rokaeus 4. Microanatomy and Chemical Coding of Peptide-Containing Neurons in the Digestive Tract E. Ekblad, R Hakanson, and F. Sundler 5. Neuropeptide Motor Actions Vary between In Vivo and In Vitro Experimental Conditions Jo-Ann E.t. Fox-Thelkeld 6. Receptors for Neuropeptides (Neurokinins) : Functional Studies D. Regoli, S. Dion, and G. Drapeau 7. Receptors for Neuropeptides: Ligand Binding Studies Sultan Ahmad, H.D. Allescher, and C.Y. Kwan 8. Receptors for Neuropeptides: Receptors Isolation Studies and Molecular Biology Jean-Pierre Vincent and Patrick Kitabgi 9. Gastrointestinal Neuropeptides and Second Messenger Systems Peter Kostka 10. Gastrointestinal Neuropeptide-Inactivating Mechanisms in the Circulation and in the Gastrointestinal Tract Frederic Checler 11. Postulated Physiological and Pathophysiological Roles on Motility Hans-Dieter Allescher and Sultan Ahmad 12. Physiological and Pathophysiological Roles of VIP, Somatostatin, Opioids, Galanin, GRP, and Secretin Jan D. Huizinga and Julio Pintin-Quezada 13. Effects of Neuropeptides on Intestinal Ion Transport P.K. Rangachari 14. The Role of Neuropeptides in the Normal and Pathophysiological Control of Blood Flow John S. Smeda 15. Neuropeptides and Cell Proliferation David J. Hill 16. Perspectives for the Study of Gut Neuropeptides E.E. Daniel

Edwin E. Daniel, Ph.D., is Professor of Biomedical Sciences, Acting Head of the Division of Physiology and Pharmacology, and Director of the Honours Program in Biology Pharmacology at McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.