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karamyan vardan t. (curatore); stowe ann m. (curatore) - neural repair

Neural Repair Methods and Protocols


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Lingua: Inglese


Pubblicazione: 01/2023
Edizione: 1st ed. 2023


This detailed collection explores a diverse range of topics related to neural repair and functional recovery following ischemic stroke. Techniques detailed in this book span from basic to emerging approaches used to evaluate hallmarks of neurorepair, including axonal remodeling and dendritic arborization, plasticity and functional connectivity, angiogenesis, neuroinflammation, and recovering cerebral blood flow. In addition, several chapters focus on rodent stroke models and post-stroke functional evaluation, clinically-relevant therapeutic paradigms and co-morbidities, pharmacotherapy and methods of delivery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Neural Repair: Methods and Protocols serves as an ideal guide for the wide community of researchers interested in neurorepair following stroke and other forms of CNS injury.


Part I: Stroke Models and Surgical Interventions


1. Rodent Stroke Models to Study Functional Recovery and Neural Repair

            Daimen R.S. Britsch, Nausheen Syeara, Ann M. Stowe, and Vardan T. Karamyan


2. Subcortical White Matter Stroke in the Mouse: Inducing Injury and Tracking Cellular Proliferation

            Miguel Alejandro Marin, Amy J. Gleichman, Andrew J. Brumm, and S. Thomas Carmichael


3. A Low Budget Photothrombotic Rodent Stroke Model

            Faisal F. Alamri, Serob T. Karamyan, and Vardan T. Karamyan


4. Photothrombotic Model to Create an Infarct in the Hippocampus

            Elena Blanco-Suárez


5. Bilateral Carotid Artery Stenosis and Cerebral Blood Flow Outcomes

            Ifechukwude Joachim Biose and Gregory Jaye Bix


6. Internal Carotid Artery Stenosis: A Surgical Mouse Model to Study Moyamoya Syndrome

            Jill M. Roberts and Justin F. Fraser


7. Modeling Distal Middle Cerebral Artery Occlusion in Neonatal Rodents with Magnetic Nanoparticles or Magnetized Red Blood Cells

            Jie-Min Jia and Yuxiao Jin


Part II: In Vivo and Post-Mortem Imaging of Mechanisms of Recovery


8. In Vivo Imaging of the Structural Plasticity of Cortical Neurons after Stroke

            Emilia Conti, Francesco Saverio Pavone, and Anna Letizia Allegra Mascaro


9. Measurement of Uninterrupted Cerebral Blood Flow by Laser Speckle Contrast Imaging (LSCI) during the Mouse Middle Cerebral Artery Occlusion Model by an Inverted LSCI Setup

            Sung-Ha Hong, Andrea Doan, and Sean P. Marrelli


10. Multi-Exposure Speckle Imaging for Quantitative Evaluation of Cortical Blood Flow

            Adam Santorelli, Colin T. Sullender, and Andrew K. Dunn


11. Wide-Field Optical Imaging in Mouse Models of Ischemic Stroke

            Jonah A. Padawer-Curry, Ryan M. Bowen, Anmol Jarang, Xiaodan Wang, Jin-Moo Lee, and Adam Q. Bauer


12. Post-Mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-Stroke Rodent Brain

            Vera H. Wielenga, Rick M. Dijkhuizen, and Annette Van der Toorn


Part III: Methods to Identify Molecular and Immune Mechanisms Supporting Recovery


13. Quantitative Spatial Mapping of Axons across Cortical Regions to Assess Axonal Sprouting after Stroke

            Mary T. Joy, Samuel P. Bridges, and S. Thomas Carmichael


14. Quantitative Evaluation of Cerebral Microhemorrhages in the Mouse Brain

            Rudy Chang and Rachita K. Sumbria


15. In Vivo Evaluation of BBB Integrity in the Post-Stroke Brain

            Yong Zhang, Saeideh Nozohouri, and Thomas J. Abbruscato


16. High Resolution RNA Sequencing from PFA-Fixed Microscopy Sections

            Hao Ji, Simon Besson-Girard, Peter Androvic, Buket Bulut, Lu Liu, Yijing Wang, and Ozgun Gokce


17. FACS to Identify Immune Subsets in Mouse Brain and Spleen

            Mary K. Malone, Thomas A. Ujas, Katherine M. Cotter, Daimen Britsch, Jenny Lutshumba, Jadwiga-Turchan-Cholewo, and Ann M. Stowe


18. A Guide on Analyzing Flow Cytometry Data Using Clustering Methods and Non-Linear Dimensionality Reduction (tSNE or UMAP)

            Thomas A. Ujas, Veronica Obregon-Perko, and Ann M. Stowe


19. Co-Culturing Immune Cells and Mouse-Derived Mixed Cortical Cultures with Oxygen-Glucose Deprivation to In Vitro Simulate Neuroinflammatory Interactions after Stroke

            Thomas A. Ujas, Vanessa O. Torres, and Ann M. Stowe


Part IV: Behavioral Methods for Quantifying Functional Recovery


20. Assessing Depression and Cognitive Impairment Following Stroke and Neurotrauma: Behavioral Methods for Quantifying Impairment and Functional Recovery

            Karienn A. de Souza, Michelle Hook, and Farida Sohrabji


21. Use of an Automated Mouse Touchscreen Platform for Quantification of Cognitive Deficits after Central Nervous System Injury

            Katherine M. Cotter, Grace L. Bancroft, Harley A. Haas, Raymon Shi, Andrew N. Clarkson, Matthew E. Croxall, Ann M. Stowe, Sanghee Yun, and Amelia J. Eisch


22. Using Operant Reach Chambers to Assess Mouse Skilled Forelimb Use after Stroke

            Dene M. Betz, April M. Becker, Katherine M. Cotter, Andrew M. Sloan, Ann M. Stowe, and Mark P. Goldberg


23. The Finer Aspects of Grid-Walking and Cylinder Tests for Experimental Stroke Recovery Studies in Mice

            Nausheen Syeara, Sounak Bagchi, Abdullah Al Shoyaib, Serob T. Karamyan, Faisal F. Alamri, and Vardan T. Karamyan


24. Performing Enriched Environment Studies to Improve Functional Recovery

            Daniela Talhada and Karsten Ruscher


Part V: Neurotherapeutics and Functional Recovery


25. Clinically-Applicable Experimental Design and Considerations for Stroke Recovery Preclinical Studies

            Vardan T. Karamyan


26. Hydrogels and Nanoscaffolds for Long-Term Intraparenchymal Therapeutic Delivery after Stroke

            Mozammel H. Bhuiyan, Josh Houlton, and Andrew N. Clarkson


27. Reverse Translation to Develop Post-Stroke Therapeutic Interventions during Mechanical Thrombectomy: Lessons from the BACTRAC Trial

            Benton Maglinger, Jacqueline A. Frank, Justin F. Fraser, and Keith R. Pennypacker


28. Methods to Study Drug Uptake at the Blood-Brain Barrier Following Experimental Ischemic Stroke: In Vitro and In Vivo Approaches

            Robert D. Betterton, Erica I. Williams, Kelsy L. Nilles, Thomas P. Davis, and Patr

Altre Informazioni



Condizione: Nuovo
Collana: Methods in Molecular Biology
Dimensioni: 254 x 178 mm Ø 1143 gr
Formato: Copertina rigida
Illustration Notes:XVI, 492 p. 125 illus., 118 illus. in color.
Pagine Arabe: 492
Pagine Romane: xvi

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