Nanotoxicology Progress toward Nanomedicine, Second Edition

Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines. Topics include The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products—with a focus on potential health and safety implications Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels Toxicity of nanomaterials to specific organ systems, cell–based targeting to tumors, and other biomedical applications The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies A roadmap for future research The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.

Impacts of Nanotechnology on BiomedicineIntroduction to Biomedical Nanotechnology; Dorothy Farrell, George Hinkal, and Piotr GrodzinskiImpact of Bionanointeractions of Engineered Nanoparticles forNanomedicine; Stefania SabellaRational Approach for the Safe Design of Nanomaterials; Anna L. CostaCharacterization of Manufactured Nanomaterials, Dispersion, and Exposure for Toxicological Testing; Keld A. Jensen, Giulio Pojana, and Dagmar BilanicováExposureWorkplace Inhalation Exposure to Engineered Nanomaterials:Detection, Measurement, and Assessment; Araceli Sánchez Jiménez, Derk Brouwer, and Martie Van TongerenNanotechnology in Consumer Products: Addressing PotentialHealth and Safety Implications for Consumers; Treye A. ThomasModelingQuantitative Nanostructure–Activity Relationships: FromUnstructured Data to Predictive Models for DesigningNanomaterials with Controlled Properties; Denis Fourches and Alexander TropshaPharmacokinetics and Biodistribution of Nanomaterials; Jim E. RiviereMethodologies and TechniquesAdvanced Methodologies and Techniques for AssessingNanomaterial Toxicity: From Manufacturing to NanomedicineScreening; Adriele Prina-Mello, Bashir M. Mohamed, Navin K. Verma, Namrata Jain, and Yuri VolkovDetection Methods for the In Vivo Biodistribution of IronOxide and Silica Nanoparticles: Effects of Size, SurfaceChemistry, and Shape; Heather A. Enright and Michael A. MalfattiQuantitative Single-Cell Approaches to Assessing Nanotoxicity inNanomedicine Systems; James F. LearyImaging Techniques for Nanoparticles in Skin; Tarl W. ProwHazardsSafety Implications of Nanomaterial Exposure to Skin; Nancy A. Monteiro-RiviereInterspecies Comparisons of Pulmonary Responses toFine and/or Nanoscale Particulates: Relevance for Humans ofParticle-Overload Responses in the Rat Model; David B. Warheit and Kenneth L. ReedCurrent In Vitro Models for Nanomaterial Testing inPulmonary Systems; Sonja Boland, Sandra Vranic, Roel Schins, and Tobias StögerNanoparticles and the Immune System; Bengt Fadeel and Diana BoraschiCarbon Nanotubes and Cardiovascular Disease; Peter Møller, Cao Yi, Lise K. Vesterdal, Pernille H. Danielsen, Martin Roursgaard, Henrik Klingberg, Daniel V. Christophersen, and Steffen LoftSingle- and Multi-walled Carbon Nanotubes Toxicity andPotential Applications in Neuroregeneration; Fariborz Tavangarian, Guoqiang Li, and Yiyao LiCurrent In Vitro Models for Nanomaterial Testing: TheReproductive System; Gary R. Hutchison and Bryony L. RossCurrent In Vitro Models for Nanomaterial Testing: GenotoxicityIssues; Laetitia Gonzalez, Sara Corradi, and Micheline Kirsch-VoldersCell-Based Targeting of Anticancer Nanomaterials to Tumors; Matt Basel, Tej Shrestha, Hongwang Wang, and Stefan BossmannSilver Nanoparticles in Biomedical Applications; Meghan E. Samberg and Nancy A. Monteiro-RiviereCytotoxicity of Conjugated and Unconjugated Semiconductor andMetal Nanoparticles; Jay NadeauRisk AssessmentIssues Related to Risk Assessment of Nanomaterials; Maureen R. GwinnRisk Assessment of Engineered Nanomaterials: State of theArt and Roadmap for Future Research; Danail Hristozov, Laura MacCalman, Keld A. Jensen, Vicki Stone, Janeck Scott-Fordsmand, Bernd Nowack, Teresa Fernandes, and Antonio MarcominiIndex

Nancy A. Monteiro-Riviere is a Regents Distinguished Research Scholar and University Distinguished Professor of toxicology and director of the new Nanotechnology Innovation Center of Kansas State. C. Lang Tran is the head of toxicology at the Institute of Occupational Medicine, Edinburgh, United Kingdom.