Nanobioceramics for Bone Tissue Engineering and Regenerative Biomedicine Tunable Biological Characteristics

This book presents the tunable biological characteristics of nanobioceramics and focuses on some challenges in bone tissue engineering and regenerative medicine. Synthetic composite-based materials and scaffolds should be biodegradable, biocompatible and supply sufficient structural aid for cell migration, along with oxygen, waste, and nutrient carriage to accelerate bone regeneration process and remodeling in defects. These properties may be reached by functioning tunable physical features, including absorption rate, degradation rate, modulus, porosity, and swelling by adjustments with the addition of ceramic phases and copolymers as synthetic composite scaffolds. Synthetic bioceramics seek to imitate the natural hydroxyapatite (HA) crystal creation located in bone. These ceramics, particularly calcium phosphates, have exhibited great osteoinductivity, osteoconductivity, and biocompatibility. Lately, silicon-based glass-ceramics have been investigated as a substitution of calcium phosphates. Several members of this collection exhibit high bioactivity, have attractive mechanical strength, and are known to increase cell proliferation, adhesion, and mineralization of extracellular matrix. Moreover, antibacterial properties of some nanostructured bioceramics established significant interests in avoiding implants rejection in surgery and biomedicine.

Introduction.- Bone.- Bone Cells.-  Bone Extracellular Matrix.- Bone ECM Proteins Part I.- Bone ECM Proteins Part II.- Bioactivity and Osteogenic Features.- Nano-Bioceramics.- Composites for BTE.

Reza Gholami obtained his master's degree in Nanotechnology-Nanomaterials Engineering from Iran University of Science and Technology. He also obtained his bachelor's degree in Chemical Engineering from Islamic Azad University, Science and Research Branch. He ranked among the top three students in his faculty during his studies. Since 2019, he has been investigating novel nanomaterials and therapies for various cancers, particularly nano-bioceramics and bone-related malignancies, at the Motamed Cancer Institute as a research assistant. Since 2022, he has maintained his role as Laboratory Director of the chemical and cell culture laboratories at Motamed Cancer Institute. Possessing more than five years of research experience in nano-biomaterials, nanoparticles, nanocarriers, nano-bioceramics, cancer studies, and nano-biosensors, he is recognized as a talented young researcher in these fields. 

Dr. Seyed Morteza Naghib received his Ph.D. in biomedical engineering from Tehran Polytechnique (2014) and M.ASc. (2010) and B.ASc. (2009) degrees from Amirkabir University of Technology both in biomedical engineering (biomaterials). His research interests are in the areas of tissue engineering, medical nanotechnology, nanobiomaterials, nanocarriers, and nanobiosensors. He also published 3 books in the field entitled "Localized Micro/Nanocarriers for Programmed and On-Demand Controlled Drug Release", "Electrochemical Biosensors in Practice: Materials and Methods", and "Green plant extract-based synthesis of multifunctional nanoparticles and their biological activities".