Microcapsules and Nanoparticles in Medicine and Pharmacy

First published in 1992: This book provides a comprehensive look at the design and production of microcapsules, microspheres, and nanoparticles. It discusses the diverse aspects and skills that must be mastered to prepare and test products that will work correctly and be clinically acceptable for human or animal use.

1. Introduction and Overview Max Donbrow Part 1: Advances in Production Technology and Characterization Of Microcapsules, Microspheres, and Nanoparticles 2. Developments in Phase Separation Methods, Aggregation Control, and Mechanisms of Microencapsulation Max Donbrow 3.Formation of Degradable Drug-Loaded Microparticles by In-Liquid Drying Processes Curt Thies 4. Fluid-Bed Spray Coating K. Lehmann 5. Polyanhydride Microspheres as Drug Delivery Systems Edith Mathiowitz and Robert Langer 6. Nanoparticles - Preparation and Applications J. Kreuter 7. Recent Advances Using Microencapsulation for Taste Masking of Bitter Drugs J.A. Bakan et al. Part 2: Biological Transit and Interactions, Release Kinetics, Pharmacokinetics And Bioavailability 8. Gastrointestinal Transit of Microcapsules John T. Fell 9. Interaction of Microcapsules with Blood Components Tamotsu Kondo 10. Recent Advances in Microencapsulation of Drugs to Obtain Reduced Gastric Irritation J.A. Bakan et al. 11. In Vitro Release from Microcapsules and Microspheres Ivan Jalsenjak 12. The Relation of Release Profiles from Ensembles to Those of Individual Microcapsules and the Influence of Types of Batch Heterogeneity on Release Kinetics Max Donbrow 13. Pharmacokinetic Considerations Related to Bioavailability of Sustained-Release Microencapsulated Drugs for Oral Use - Assessment of Absorption Rates Shigeru Goto and Takahiro Uchida Part 3: Clinical Applications, Targeting, and Living and Artificial Encapsulated Cells. 14. Clinical Uses of Microcapsules and Microspheres Kazuhiko Juni and Masahiro Nakano 15. Chemo-Embolization and Passive Targeting with Degradable Starch Microspheres Peter Edman and Ingvar Sjöholm 16. Active Targeting of Microcapsules and Microspheres to Specific Regions Julia J. Wright and Lisbeth Illum 17. Erythrocytes as Microvesicles David A. Lewis and H. Oya Alpar 18. Microencapsulation of Living Cells and Tissues. Anthony M. Sun, Ivan Vacek, and Isaballa Tai 19. Recent Advances in Artificial Cells with Emphasis on Biotechnological Approaches Based on Microencapsulation Thomas Ming Swi Chang

Max Donbrow, Ph.D., D.Sc., is Professor of Pharmacy at the Hebrew University of Jerusalem, Jerusalem, Israel.