Metabolome Analyses: Strategies for Systems Biology

Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems.

The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.

Towards Integrative Functional Genomics Using Yeast as a Reference Model.- Metabolomics for the Assessment of Functional Diversity and Quality Traits in Plants.- Metabolomics: A New Approach Towards Identifying Biomarkers and Therapeutic Targets in CNS Disorders.- Comparative Metabolome Profiling Using Two Dimensional Thin Layer Chromatography (2DTLC).- Capillary Electrophoresis and Its Application in Metabolome Analysis.- Metabolite Profiling with GC-MS and LC-MS.- The Application of Electrochemistry to Metabolic Profiling.- Differential Metabolic Profiling for Biomarker Discovery.- NMR-Based Metabonomics in Toxicology Research.- Methodological Issues and Experimental Design Considerations in Metabolic Profile-Based Classifications.- Modelling of Fungal Metabolism.- Detailed Kinetic Models Using Metabolomics Data Sets.- Metabolic Networks.- Metabolic Networks from a Systems Perspective.- Parallel Metabolite and Transcript Profiling.- Fluxome Profiling in Microbes.- Targeted Drug Design and Metabolic Pathway Flux.- Metabonomics in the Pharmaceutical Industry.- How Lipidomic Approaches Will Benefit the Pharmaceutical Industry.- Metabolites and Fungal Virulence.