Mechanochemistry and Emerging Technologies for Sustainable Chemical Manufacturing

This unique volume describes advances in the field of mechanochemistry, in particular the scaling up of mechanochemical processes. Scalable techniques employed to carry out solvent-free synthesis are evaluated. Comparability to continuous flow chemistry, the current industrial benchmark for continuous efficient chemical synthesis, is presented.The book concludes that mechanochemical synthesis can be scaled up into a continuous, sustainable process. It demonstrates that large-scale mechanochemistry can meet industrial demands, especially in the pharmaceutical industry.  Features Mechanochemistry is rapidly developing as a multidisciplinary science on the borderline between chemistry, materials science and environmental science. This unique text focuses on mechanochemistry with the ability to scale up and illustrates how mechanochemical synthesis is no longer an obstacle. This timely book highlights recent advancements describing what can be achieved in chemical synthesis. Mechanochemistry enables the synthesis of multiple polymorphic crystalline forms in the production of drugs in the form of tablets or granules in capsules.

Foreword Sepelak Vladimir Introduction Felipe Garcia and Evelina Colacino Mechanochemistry – A general introduction : Mechanochemical Based Technologies In situ monitoring of mechanochemical ball-milling reactions Ivan Halasz, Stipe Lukin and Tomislav Friscic The thermodynamics and kinetics of mechanochemical reactions: a computational approach Bruna S Pladevall and Feliu Maseras The Thermodymanics and Kinetics of Mechanochemical Reactions: An experimental Approach Adam A.L. Michalchuk Life cycle assessment: a tool for sustainability evaluation of emerging mechanochemical process engineering Sabrina Spatari, Or Galant and Charles E. Diesendruk Relevance of the IP strategy for the implmentation of sustainable manufacturing bymechanochemistry Tanja Bendele Solvent-free Sustainable Technologies at large scale Mechanochemistry and industry:process intensification and beyond Valerio Isoni On the theory and recent developments in "batch mechanochemical synthesis – scale-up" Steffen Reichle and Michael Fellderhoff Acoustic synthesis (solvent-free) and Resonant Acoustic Mixing (RAM) Maria Elena Rivas Case studies/perspective Sustainable large scale manufacturing of fine chemicals, active pharmaceutical ingredientsand biologically active compounds by non-traditional activation methods and biocatalysis Manisha Mishra and Bela Torok Eccentric vibration milling for mechancochemical synthesis: a straightforward route to advanced materials Peter Balaz, Macela Achimovicova, Erika Dutkova and Matej Balaz Scalable solutions for continuous manufacturing by mechanochemical-assisted synthesis Jamie A. Leitch, Matthew T.J. Williams, and Duncan Browne Reduced Solvent Sustainable Technologies Large-Scale Flow Chemistry Nicole Neyt, Jaimee Jugmohan, Wessel Bonnet, Jenny-Lee Panayides and Darren Riley Sustainable synthesis of API in water in industrial settingNing Ye and Fabrice Gallou

Evelina Colacino received her double Ph.D. (with European Label) in 2002 at the University of Montpellier II (France), and at the University of Calabria (Italy). She was appointed Research Fellow at the Catholic University of Louvain (Belgium, 2003), working on the preparation of new hydantoin scaffolds as antibacterial agents. Research Scientist at Sigma- Tau Pharmaceuticals (Italy, 2004), Post-Doctoral Fellow University of Montpellier II, (France, until 2007), she was hired as Assistant Professor in 2008. Associate Professor of Organic and Green Chemistry since 2013, at the University of Montpellier, France, her main research activities concern the development of eco-friendly methodologies for the preparation of biomolecules, heterocyclic compounds and hybrid materials by mechanochemistry, with a main focus on Active Pharmaceutical Ingredients (medicinal mechanochemistry). She also investigates sustainable approaches to homogeneous or heterogeneous metal-catalysed processes by combining enabling technologies with non-conventional media. She is also promoter of sustainability in Higher Education by integrating green chemistry at undergraduate level in organic chemistry courses, teaching laboratories and across the sub-disciplines of chemistry, with a special focus on the fundamentals and the practice of mechanochemistry. She is member of the Advisory Board of the Green Chemistry Commitment (GCC, www.beyondbenign.org) and the International Mechanochemical Association (IMA, http://imamechanochemical.com). She leads the European Programme COST Action CA18112 (MechSustInd, 2019-2023) – ‘Mechanochemistry for Sustainable Industry (www.mechsustind.eu and https://www.cost.eu) and the EU Horizon Project IMPACTIVE (Innovative Mechanochemical Processes to synthesise green ACTIVE pharmaceutical ingredients, 2022-2026). Felipe García is originally from the coastal town of Gijon (Spain) and gained both his B.Sc. and M.Sc. degrees in Chemistry at the local Oviedo University (Spain). In 2001, he moved to the University of Cambridge (UK) to carry out his graduate studies on main group imides and phosphides as a Cambridge European Trust and Newton Trust Scholar under the supervision of Prof. Dominic Wright. He then gained Junior Research Fellowship at Wolfson College (UK, 2005) and was appointed College Lecturer in Inorganic Chemistry at Newnham and Trinity Colleges (UK, 2006). In March 2011, he moved to Nanyang Technological University (Singapore) as Assistant Professor, where he developed different aspects of main group chemistry. In 2022, he moved back to his alma mater (i.e., University of Oviedo) as a Margarita Salas Senior researcher (funded by FICYT). The Margarita Salas Senior programme is a new scheme from the Foundation for the Promotion in Asturias of Applied Scientific Research and Technology (FICYT) to attract highly qualified well-established researchers to R&D and higher education institutions in the Principality of Asturias (Spain). In late 2023, he will move to Monash University in Australia continue his research career. Felipe has published over 90 papers on Main Group Chemistry and maintains a strong interest in the synthesis of novel compounds for industrial and biological applications.