Mechanobiology of Living Systems

This text brings together mechanobiology theory, approaches, and applications in a format appropriate for readers with some mathematical and biological exposure. It begins by explaining fundamental mechanobiological principles in a sequential "ground up" approach that includes key terminology. Next, it identifies the in vivo mechanical environment of biological systems—highlighting areas of important research. Maintaining a focus on mechanobiology fundamentals, it includes example questions drawn from a variety of organ systems, lower organisms, and plants. This comprehensive resource includes example problems drawn fromtheory and applications in each chapter, as well as sections on experimental methods.

IntroductionMolecular MechanobiologyMechanics of Adhesion and SignalingMigrationMatrix StiffnessStrain Based MechanotransductionHemodynamics Based SignalingGravityMechanobiology of Growth and RemodelingMechanobiology of PlantsMechanobiology in Lower OrganismsMechanobiology of the HeartMechanobiology of the Skeletal SystemMechanobiology of Connective TissueDevelopmental BiomechanicsOther Applications to Draw Exercises FromAppendicesSolutions to Exercises

Jonathan T. Butcher initiated a research program focused on understanding the roles of mechanical forces in shaping cardiovascular morphogenesis and adult disease with an emphasis on heart valves. Long term objectives to use developmental paradigms to discover novel disease paradigms and regenerative strategies. This research program focusses on the following three areas: Cardiovascular Developmental Mechanobiology; Developmental Paradigms in Postnatal Valve Disease; and Heart Valve Tissue Engineering.