Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3 Basic Science and Clinical Relevance Part B

During the past several decades, a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays a critical role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in numerous individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perforation of the cornea, an increased incidence of infectious disease, and potentionally pronounced visual disability and blindness.

Immunity and Inflammation I: Influence of Cytokines, Chemokines, Adhesion Molecules and Other Immunoactive Agents.- Immunity and Inflammation II: Role of Apoptosis, Antibodies and Mucosal Associated Lymphoid Tissue.- Contact Lenses: Impact on the Tear Film and Ocular Surface.- Epidemiology and Pathogenesis of Dry Eye Syndromes (e.g. Sjögren’s Syndrome).- Dry Eye Syndromes: Diagnosis, Clinical Trials and Pharmaceutical Treatment.- Gene, Stem Cell and Surgical Therapy of the Ocular Surface.- Closing Session.- Addendum.