Preface.- 1. M.M.Fischer,J.Fröhlich, Knowledge,Complexity and Innovation Systems: Prologue.- Part A: Innovation Systems: 2. P.P.Saviotti, Networks,National Innovation Systems and Self-Organisation; 3. C.Edquist, Innovation Policy in the Systems of Innovation Approach: Some Basic Principles; 4. D.Archibugi, The Globalisation of Technology and the European Innovation System.- Part B: Knowledge Creation and Spillovers: 5. A.Lagendijk, Scaling Knowledge Production: How Significant is the Region? 6. C.Karlsson,A.Manduchi, Knowledge Spillovers in a Spatial Context - A Critical Review and Assessment; 7. M.M.Fischer,J.Fröhlich;H.Gassler,A.Varga, The Role of Space in the Creation of Knowledge in Austria - An Exploratory Spatial Analysis; 8. E.Echeverri-Carroll, Knowledge Spillovers in High Technology Agglomerations: Measurement and Modelling.- Part C: Innovation, Knowledge and Regional Development: 9. L.Suarez-Villa, Inventive Knowledge and the Sources of New Technology: Regional Changes in Innovative Capacity in the United States; 10. R.Capello, Urban Innovation and Collective Learning: Theory and Evidence from Five Metropolitan Cities in Europe; 11. N.Alderman, Distributed Knowledge in Complex Engineering Project Networks: Implications for Regional Innovation Systems; 12. Z.J.Acs, Endogenous Technological Change, Entreneurship and Regional Growth.- Part D: Modelling Complexities: 13. G.Haag,P.Liedl, Modelling of Knowledge, Capital Formation, and Innovation Behaviour within Micro-Based Profit Oriented and Correlated Decision Processes; 14. F.Schweitzer,J.Zimmermann, Communication and Self-Organisation in Complex Systems: A Basic Approach; 15. D.F.Batten, Agents, Interactions, and Co-Evolutionary Learning; 16. M. Sonis, Major Actors of Innovation Diffusion Process.- Part E: Policy Issues: 17. D.Dendrinos, Options, Innovation and Metropolitan Development: Novel Insights from Non-Linear Dynamics; 18. P.Nijkamp,J.Poot,G.Vindigni, Spatial Dynamics and Government Policy: An Artificial Intelligence Approach to Comparing Complex Systems; 19. D.Engel,A.Fier, Does R&D-Infrastructure Attract High-Tech Start-Ups?.- References.- List of Figures.- List of Tables.- Subject Index.- Author Index.- List of Contributors