Ion Channels Molecules in Action

Up-to-date introduction to ion channels and how they work, emphasising their molecular structure.

Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.

Preface; 1. Introduction; 2. Ions on the move; 3. Investigating channel activity; 4. Molecular structures; 5. Permeability and selectivity; 6. Gating and modulation; 7. Drugs and toxins; 8. Dysfunctional channels in human disease; 9. Not the last word; References; Index.

Located in cell membranes, ion channels determine the passage of ions across them. Ion Channels examines the molecular structure of channels, which helps explain their permeability and selectivity, their gating and modulation, their responses to drugs and toxins, and the diseases caused when they do not function properly.