Insulin-like Growth Factors Molecular and Cellular Aspects

During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.

The IGF-I Gene: Structure, Expression, and Gene Products. The Insulin-Like Growth Factor I Receptor: Molecular Biology, Heterogeneity and Regulation. Biological Actions of the Insulin-Like Growth Factors. Insulin-Like Growth Factor II: Gene Structure and Expression into Messenger RNA and Protein. The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor. Insulin-Like Growth Factor Binding Proteins. Insulin. Structure and Function of the Insulin Receptor. Is Insulin a Growth Factor? Regulation of Insulin, IGF-I and IGF-II Gene Expression.Molecular (genetic) aspects of growth factorsBinding proteins and receptorsFactors affecting gene transcription and translation