This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression…) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.
1. Overview of immune influence on the brain
The end of immune privilege Louveau A , US
Cytokines as brain signalling pathways Michael Maes/Brian Leonard
Immune system and neurodevelopment Michal Schwartz, Israel
Role of microglia in brain development Beth Stevens, US
Brain antigens and antibodies Laurent Groc, France
Complement and Major Histocompatibility Complex involvment in the brain Cai Song
Brain blood barrier Gerwyn Morris
Brain imaging to explore immune activation in the brain Lyliane Nasib, Utrecht, NL
2. Immune mechanisms and pathways leading to psychiatric disorders
Perinatal infections in psychiatric disorders Alan Brown, US
Auto-immune disorders as risk factors Michael Benros, Den
Role of cytokines in the psychiatric disorders Nicolas Glaichenhaus, France
Stress as a mediator of inflammation Carmine Pariante, UK
Role of Oxidative stress Ana Andreazza, Canada
Role of Endogenous retrovirus in psychiatry Hervé Perron, France
Immuno-genetic background Ryad Tamouza, France
Gene-environment interactions Rudolf Uher
Gut to the brain John Cryan, UK
The complement pathway in the risk for schizophrenia Aswin Sekar, US
3. Immune dysfunctions and psychiatric disorders
Is Autism Spectrum Disorder related to immune dysfunction Van de Water, US
Inflammation and immunity in Schizophrenia Bob Yolken, US
Dysimmunity and Bipolar disorder Hemmo Drexhage, NL
Immune dysfunction and Major depressive disorder Robert Dantzer, US
Immune dysfunction and OCD &n
Michael Berk is an NHMRC Senior Principal Research Fellow at Deakin University, where he heads the IMPACT institute. He is listed by Thompson Reuters as amongst the world’s most influential scientific minds (2015-2020) and was awarded the Brain & Behaviour (NARSAD) Colvin Award for Mood Disorders in 2015, the Victoria Prize for life sciences in 2019 and the International Society for Bipolar Disorders Bob Post award for mentorship in 2020. He is past president of the International Society for Bipolar Disorders and the Australasian Society for Bipolar and Depressive Disorders. His major interests are in the discovery and implementation of novel therapies.
Marion Leboyer M.D., Ph.D. is Professor of Psychiatry at the University of Paris Est Créteil (UPEC) in France. She is Head of the University-affiliated Department of Psychiatry and Addiction, DMU IMPACT (Hôpitaux Universitaires Mondor, Assistance-Publique-Hôpitaux de Paris) and runs the “Translational Neuro Psychiatry” laboratory which is part of the Mondor Institute for Biomedical Research (Inserm U955). Since 2007, she has been the Executive Director of the non profit foundation, “Fondation FondaMental”, created by the French Ministry of Research. She is President of the ECNP Immuno-psychiatry TWG. She is listed as a highly cited researcher in 2020.Iris Sommer MD, PhD is a Professor of Psychiatry working at the Biomedical and Psychiatry Departments of the University Medical Center Groningen (UMCG) in the Netherlands. She is an expert in psychotic disorders and leads several trials aiming to improve treatment in this patient group. She is an associate editor of Lancet Psychiatry and Psychological Medicine, and a board member of ECNP and SIRS. She is a founding member of the International Consortium of Hallucination Research and initiated the Gordon Research Conference cycle on cognitive dysfunction in brain disorders together with Prof. Linda Lam from the Chinese University of Hong Kong. In 2021, she was elected member of the Royal Holland Academy of Science.
Utilizziamo i cookie di profilazione, anche di terze parti, per migliorare la navigazione, per fornire servizi e proporti pubblicità in linea con le tue preferenze. Se vuoi saperne di più o negare il consenso a tutti o ad alcuni cookie clicca qui. Chiudendo questo banner o proseguendo nella navigazione acconsenti all’uso dei cookie.