Immune Cells, Inflammation, and Cardiovascular Diseases

Inflammation, once considered a physiological response to foreign pathogens, is now recognized as a crucial pathological player in the initiation and progression of several chronic diseases, including diabetes, obesity, cancer, Alzheimer’s disease, Parkinson’s disease, and many others. Considering that cardiovascular diseases are a leading cause of death in the United States and worldwide, the identification of critical inflammatory processes is of utmost importance to devising new immune-based therapeutics that can be added to existing regimens. This book provides detailed information on aspects of inflammation and the manner in which immune activation pathways affect the progression of cardiovascular diseases and the repair/regeneration mechanisms of underlying diseased tissues. Key Features Outlines the role that inflammation plays in cardiovascular diseases Describes a paradox – neutralization of cytokines that contribute to cardiovascular disease does not show benefit Summarizes research on a variety of processes and mechanisms contributing to cardiovascular pathology Contributions from an international team of leading cardiologists and cardiovascular immunologists Related Titles Roy, S., et al., eds. Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions (ISBN 978-1-138-19955-2) Kong, A-N. T., ed. Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention (ISBN 978-1-138-19984-2) Dick, A., et al. Practical Manual of Intraocular Inflammation (ISBN 978-0-367-38720-4)

Introduction. Shyam S. Bansal. Chapter 1. Innate Immune system in Cardiovascular Diseases. Benjamin J. Kopecky and Kory J. Lavine. Chapter 2. Helper T-cells in Cardiovascular Diseases. Vinay Kumar, Sahil Gupta, Rachel Rosenzweig, Shyam S. Bansal. Chapter 3. Glucocorticoid Signaling in Heart. Danish Sayed. Chapter 4. Transforming Growth Factor (TGF)-ß/Smadsignaling in myocardial disease. Claudio Humeres and Nikolaos G Frangogiannis. Chapter 5. Fibroblast and Immune Cell crosstalk in Cardiac Repair. Stelios Psarras and Georgina Xanthou. Chapter 6. Inflammation, Stem Cell Therapy, and Cardiac Repair. Marcus J. Wagner, Jacob T. Menzer, and Sadia Mohsin. Chapter 7. Cardiovascular Complications of Immune Checkpoint Inhibitors. Sultan Tousif, Anand Prakash Singh, Prachi Umbarkar, and Hind Lal. Chapter 8. Neuronal Regulation of immune system in Cardiovascular Diseases. Daniela Carnevale, Giuseppe Lembo, Marialuisa Perrotta, and Lorenzo Carnevale. Chapter 9. Immune Responses Regulated by Exosomal Mechanisms in Cardiovascular Disease. Brooke Lee, Ioannis D. Kyriazis, Ruturaj Patil, Syed Baseeruddin Alvi, Amit Kumar Rai, Mahmood Khan, and Venkata Naga Srikanth Garikipati. Chapter 10. Ion Channels in Immune Cells: Physiological and Pathophysiological Roles. Devasena Ponnalagu, Shridhar Sanghvi, Shyam Sunder Bansal, and Harpreet Singh.

Shyam S. Bansal is a a cardiovascular immunologist with expertise in the immune-inflammatory pathways of myocardial infraction and heart failure. His research endeavors focus on the elucidation of innate (macrophages and dendritic cell) and adaptive (T-cells) immune responses during chronic heart failure and the role of these immune cells in mediating pathological left-ventricular remodeling. He is particularly interested in deciphering the role of T-cell subsets and time-dependent phenotypic changes that these cells undergo during chronic HF. He is also interested in identifying and developing novel therapeutic strategies to reverse pathological changes in the immune cells for their bench-to-bed transition. Shyam S. Bansal is an Assistant professor in the Department of Physiology and Cell Biology at the Ohio State University. He received a PhD from the Department of Pharmacology & Toxicology at the University of Louisville, Louisville, KY in 2011. Bansal's first post-doctoral training was in the Department of Nanotechnology at the Methodist Hospital Research Institute (09/2011-09/2012) followed by an extensive post-doctoral training (from 09/2012-07/2018) in studying the role of helper T-cells and Regulatory T cells in mediating pathological left-ventricular remodeling and ischemic heart failure.