IGF and Nutrition in Health and Disease

A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.

I . Overview Overview and Molecular Aspects of the Insulin-Like Growth Factor System Martin L. Adamo, Lai Wang, Lisa Heron, Dalit Ben-Yosef, Hong Zhao, and Derek Le Roith II. IGF and Nutritional Status Regulation of Insulin-Like Growth Factor-I by Nutrition Jean-Paul Thissen, Véronique Beauloye, Jean-Marie Ketelslegers, and Louis E. Underwood Nutrition and IGF Proteins in Chronic Malnutrition and Critical Illness Pei-Ra Ling and Bruce R. Bistrian The Insulin-Like Growth Factors and Assessment of Nutritional Status M. Sue Houston III. Growth and Development Regulation of Growth and the Insulin Growth Factor System by Zinc Ruth S. MacDonald The Role of the Insulin-Like Growth Factor System in Pre- and Postnatal Growth, Development, and Tumorigenesis Charles T. Roberts, Jr. The Insulin-Like Growth Factor Axis in the Fetus and Neonate Cynthia L. Blanco and Robert J. Ferry, Jr. Nutrition and the IGF System in Reproduction Frank A. Simmen, Inseok Kwak, Jason L. Blum, and Rosalia C. M. Simmen The Insulin Growth Factor System and Nutrition in Adulthood and Aging Moira S. Lewitt and Kerstin Hall IV. IGF and Organ Systems Nutrition and Insulin Growth Factor-I in Relation to Bone Health and Disease Jean-Philippe Bonjour, Patrick Ammann, Thierry Chevalley, and René Rizzoli Effect of Insulin-Like Growth Factor Proteins on Skeletal Muscle Protein Metabolism During Normal and Catabolic Conditions Charles H. Lang and Robert A. Frost Insulin-Like Growth Factors and Nervous System Disorders Gary Meyer, Aparna Bole, and Eva L. Feldman The Kidney and the Insulin-Like Growth Factor System in Health and Disease Ralph Rabkin, Steven S. Guest, and Franz Schaefer V. IGF in Disease States The IGF and IGFBP System in InsulinResistance and Diabetes Mellitus Kerstin Brismar and Moira S. Lewitt Insulin-Like Growth Factors in Relation to Gastrointestinal Diseases and Parenteral Nutrition Denise M. Ney Impact of Critical Illness on the Growth Hormone/Insulin Growth Factor System in Relation to Other Endocrine Responses Greta Van den Berghe Mechanisms of Cardiac Hypertrophy and the Development of Heart Failure: Role of Insulin-Like Growth Factor-I and Angiotensin-II Patrice Delafontaine, Marijke Brink, and Yao-Hua Song Roles of the Insulin-Like Growth Factor System and Nutrition in Cancer Claire M. Perks and Jeffrey M. P. Holly Appendix A Appendix B Index