Hughes Syndrome Antiphospholipid Syndrome

The second edition of Hughes Syndrome: Antiphospholipid Syndrome addresses the complete range of conditions produced by this common disorder which is also known as APS or "sticky blood" syndrome. APS is one of the main causes of strokes (40%), leg deep vein thrombosis, and recurrent miscarriages in women. It is an important risk factor for thrombosis in women taking the oral contraceptive pill.

The effects of this syndrome were found initially in thrombosis, obstetrics (APS is the most common treatable cause of recurrent pregnancy loss) and neurology. Its impact is now felt in a diverse range of conditions. These include surgery (graft rejection), orthopedics (avascular necrosis, DVT), psychiatry (memory loss), cardiology (pulmonary hypertension, valvular disease, angina), ENT (vertigo), pediatrics (young strokes, epilepsy) to name but a few.

This new and updated text reflects the growth in published literature on APS and the widening ramifications of the disease. APS is a multi-specialty disease and is of increasing interest to obstetricians, rheumatologists, hematologists, dermatologists, neurologists and immunologists.

Clinical Aspects.- Hughes Syndrome: History.- Antiphospholipid (Hughes) Syndrome: An Overview.- Epidemiology of Antiphospholipid Syndrome.- Hemocytopenias in Antiphospholipid Syndrome.- Cardiac Manifestations in Antiphospholipid Syndrome.- Cerebral Ischemia in Antiphospholipid Syndrome.- Cerebral Disease Other than Stroke and Transient Ischemic Attack in Antiphospholipid Syndrome.- Skin Manifestations of Antiphospholipid Syndrome.- Kidney Disease in Antiphospholipid Syndrome.- Systemic Hypertension in Antiphospholipid Syndrome.- Pulmonary Hypertension and Antiphospholipid Antibodies.- Osteoarticular Manifestations of Antiphospholipid Syndrome.- The Ear and Antiphospholipid Syndrome.- The Eye in Primary Antiphospholipid Syndrome.- Primary Antiphospholipid Syndrome.- Catastrophic Antiphospholipid Syndrome.- Obstetric Antiphospholipid Syndrome.- Infertility and Antiphospholipid Antibodies.- Transplantation of Solid Organs, Tissues, and Prosthetic Devices in Patients with Antiphospholipid Antibodies.- Antiphospholipid Syndrome in Children.- Ethnic and Geographic Variation in Antiphospholipid Syndrome.- Antiphospholipid Syndrome: Differential Diagnosis.- Laboratory Investigation.- Anticardiolipin Testing.- Lupus Anticoagulants: Mechanistic and Diagnostic Considerations.- ?2-glycoprotein I and Anti-?2-glycoprotein I Antibodies.- Antiprothrombin Antibodies.- Antiphospholipid Syndrome in the Absence of Standard Antiphospholipid Antibodies: Associations with Other Autoantibodies.- Basic Aspects.- Vascular Pathology of Antiphospholipid Antibody Syndrome.- Placental Pathology in Antiphospholipid Syndrome.- Antiphospholipid Syndrome — Experimental Models: Insight into Etiology, Pathogenesis, and Treatments.- Antiphospholipid Antibody-Induced Pregnancy Loss and Thrombosis.-Mechanism of Thrombosis in Antiphospholipid Syndrome: Binding to Platelets.- Interaction of Antiphospholipid Antibodies with Endothelial Cells.- The Influence of Antiphospholipid Antibodies on the Protein C Pathway.- Contribution of Tissue Factor to the Pathogenesis of Thrombosis in Patients with Antiphospholipid Syndrome.- Annexins in Antiphospholipid Syndrome.- Plasminogen Activation, Fibrinolysis, and Cell Proteolytic Activity in Antiphospholipid Syndrome.- Lessons from Sequence Analysis of Monoclonal Antiphospholipid Antibodies.- Apoptosis and Antiphospholipid Antibodies.- Accelerated Atherogenesis and Antiphospholipid Antibodies.- Genetics of Antiphospholipid Syndrome.- Infection and Drug-Induced Antiphospholipid Antibodies.- Therapy.- Management of Thrombosis in Antiphospholipid Syndrome.- Management of Antiphospholipid Syndrome in Pregnancy.- Management of Thrombocytopenia in Hughes Syndrome.- The Future of Hughes Syndrome.