HIV-1 Proteomics From Discovery to Clinical Application

The development of proteomic analyses using advanced mass spectrometry techniques has revolutionized the way proteins are studied, namely, as individual molecules within a complex system.  HIV-1 Proteomics: From Discovery to Clinical Application comprehensively covers protein analysis from the early classic experimental days to current state-of-the-art HIV-1 proteomics in a clear informative style that brings expert-level understanding to the novice. Discussion of important clinical applications and future directions for the field also make this an ideal read for the expert. After finishing this book, the reader will have a complete and functional understanding of protein analysis from traditional biochemistry to modern proteomics.

Part I. Rebranding Classical Protein Chemistry: Proteomics of the Past.- Introduction: HIV-1 Proteomics, Why Should One Care?.- HIV-1 Biology at the Protein Level.- 25 Years of Protein Biochemistry.- Part II. Modern HIV-1 Proteomics.- Proteomics Studies of HIV-1.- HIV-1 Sequencing.- Proteomic Studies of HIV-1 and its Post-Translational Modifications.- Bioinformatics for Mass Spectrometry Based Proteomics.

David R. M. Graham, MSc, PhD

Associate Professor

Johns Hopkins School of Medicine

Molecular and Comparative Pathobiology

Baltimore, MD USA 

David E. Ott, PhD

Principal Scientist/Principal Investigator, Retrovirus-Cell Interaction Section

Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research AIDS and Cancer Virus Program

Frederick, MD USA