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Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.
Sommario
Introduction.- Familial Adenomatous Polyposis.- Historical Aspects of Lynch Syndrome.- Molecular Genetics of Familial Adenomatous Polyposis.- DNA Mismatch Repair.- Hamartomatous Polyposis.- Hyperplastic Polyposis Syndrome: Colorectal Cancer Predisposition.- MUTYH-Associated Polyposis.- Polymorphic Variation and Risk of Colorectal Cancer.- The Pathologist and the Phenotype of Hereditary Colorectal Cancer.- Genotype Phenotype Correlation in Familial Adenomatous Polyposis (FAP).- Surgery for Familial Adenomatous Polyposis.- Duodenal Adenomas in Familial Adenomatous Polyposis.- FAP Associated Desmoid Tumours.- Attenuated Familial Adenomatous Polyposis: Diagnosis, Management and Future Prognosis.- An Overview of the Lynch Syndrome (hereditary nonpolyposis colorectal cancer, HNPCC).- Surgical Management.- Extracolonic Tumors.- Surveillance.- MUTYH Associated Polyposis.- Peutz-Jeghers Syndrome.- Clinical Aspects of Juvenile Polyposis.- Hereditary Mixed Polyposis Syndrome and Multiple Adenoma Patients.- Hyperplastic Polyposis.- Genetic Counseling Overview.- Across Culture and Health Systems - Europe.- Across Culture and Health Systems - Asia (Hong Kong).- Across Culture and Health Systems - Asia (Japan).- Across Culture and Health Systems - Africa.- Across Culture and Health Systems - Argentina.- Across Culture and Health Systems - Australia.- Across Culture and Health Systems - Korea.- Across Culture and Health Systems - America.- Psychological Impact of Genetic Counseling and Testing for Hereditary Colorectal Cancers.- Chemoprevention For Inherited Colorectal Cancer.- Registries
Altre Informazioni
ISBN:
9781461426622
Condizione: Nuovo
Collana: MD Anderson Solid Tumor Oncology Series
Dimensioni: 235 x 155 mm Ø 979 gr
Formato: Brossura
Illustration Notes:XVIII, 630 p.
Pagine Arabe: 630
Pagine Romane: xviii
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