Hepatic Encephalopathy

Because of the increasing burden of hepatitis C and fatty liver disease, there is an explosion in the prevalence of chronic liver failure and hence its complications. The onset of Hepatic Encephalopathy (HE) in these patients has a significant impact on the quality of life, morbidity and mortality. Unfortunately, the approach observed by most clinicians to this complex disorder is minimalistic.

This book provides a comprehensive review on pathophysiology and clinically important aspects in HE. Topics in basic physiology, nitrogen metabolism, new insights into pathogenesis and brain edema are covered in great detail. The authors have made a special effort by simplifying the complex aspects of pathogenesis and diagnosis so that it can be easily understood and applied clinically. This volume also focuses on recent developments regarding diagnoses of subtle forms of HE, also known as minimal or covert HE as well as on new treatments. Hepatic Encephalopathy will be of great value to gastroenterologists, hepatologists, pathologists, medical residents, fellows, internists and general practitioners who treat patients with hepatic encephalopathy.

Introduction, Nomenclature and Classification of Hepatic Encephalopathy.- Role of Ammonia in the Pathogenesis of Hepatic Encephalopathy.- Neuro-inflammation in the Pathogenesis of Hepatic Encephalopathy.-Inflammation and Hepatic Encephalopathy.-Oxidative Stress in Hepatic Encephalopathy.-The Role of Natural Benzodiazepines Receptor Ligands in Hepatic Encephalopathy.- Diagnosis of Overt Hepatic Encephalopathy.-  Diagnosis of Minimal Hepatic Encephalopathy.- The Electroencephalogram in Hepatic Encephalopathy.- Brain Imaging in Hepatic Encephalopathy.- Disaccharides in the treatment of hepatic encephalopathy.-Antibiotic Treatment for Hepatic Encephalopathy.- Ornithine phenylacetate: A novel strategy for the treatment of Hepatic Encephalopathy.- Sleep Disorders and Hepatic Encephalopathy.- Hepatic Encephalopathy and Driving.- Nutrition and Hepatic Encephalopathy.- Hepatic Encephalopathy in Patients with Transjugular Intrahepatic Portosystemic Shunt (TIPS).- Quality of Life in Hepatic Encephalopathy.- Liver transplantation and Hepatic Encephalopathy.- Future of Hepatic Encephalopathy.