Handbook of Pharmaceutical Granulation Technology

This fully revised edition of Handbook of Pharmaceutical Granulation Technology covers the rapid advances in the science of agglomeration,  process control, process modelling, scale-up, emerging particle engineering technologies, along with current regulatory changes presented by some of the prominent scientist and subject matter experts around the globe. Learn from more than 50 global subject matter experts who share their years of experience in areas ranging from drug delivery and pharmaceutical technology to advances in nanotechnology. Every pharmaceutical scientist should own a copy of this fourth edition resource. Key Features: Theoretical discussions covering granulation and engineering perspectives. Covers new advances in expert systems, process modelling and bioavailability Chapters on emerging technologies in particle engineering Updated Current research and developments in granulation technologies

Preface About the Editor List of Contributors Chapter 1 Introduction, Dilip M. Parikh Chapter 2 Theory of Granulation: An Engineering Perspective, Bryan J. Ennis, Michael Winn, Brandon Ennis, Naseem Jibrin Chapter 3 Drug Substance and Excipient Characterization, Parind M. Desai, Lai Wah Chan, Paul Wan Sia Heng  Chapter 4 Binders in Pharmaceutical Granulation, Thomas Durig, Kapish Karan Chapter 5 Excipients and their Attributes in Granulation, Anthony E. Carpanzano Chapter 6 Spray Drying and Pharmaceutical Applications, Metin Celik, Pavan Muttil, Gulsilan Binzet and Susan C. Wendell Chapter 7 Emerging Technologies for Particle Engineering, Dilip M. Parikh Chapter 8 Roller Compaction Technology, Ronald Miller, Vishwas Nesarikar Chapter 9 Advances in Wet Granulation of Modern Drugs, Bing Xun TAN, Wen Chin FOO, Keat Theng CHOW, Rajeev GOKHALE  Chapter 10 Fluid Bed Processing, Dilip M. Parikh Chapter 11 Single Pot Processing, Griet Van Vaerenbergh, Harald Stahl Chapter 12 Extrusion/Spheronization as a Granulation Technique, David F. Erkoboni Chapter 13 Continuous Granulation, Chris Vervaet, Thomas De Beer, Valerie Vanhoorne Chapter 14 Effervescent Granulation, Guia Bertuzzi Chapter 15 Granulation of Plant Products and Nutraceuticals, Dilip M. Parikh Chapter 16 Granulation Approaches for Modified Release Products, Neelima Phadnis, Sree Nadkarni Chapter 17 Granulation of Poorly Water-Soluble Drugs, Albert W. Brzeczko, Firas El Saleh, Hibreniguss Terefe Chapter 18 Granulation and Production Approaches of Orally Disintegrating Tablets, Tansel COMOGLU, Fatemeh BAHADORI Chapter 19 Melt Granulation, Shana Van de Steene, Valérie Vanhoorne, Chris Vervaet, Thomas De Beer Chapter 20 Sizing of Granulation, Gurvinder Singh Rekhi, Richard Sidwell              Chapter 21 Granulation Characterization, Cecil W. Propst Chapter 22 Bioavailability and Granule Properties, Sunil S. Jambhekar Chapter 23 Granulation Process Modeling, Ian T. Cameron, Fu Y. Wang Chapter 24 Scale-Up Considerations in Granulation, Yinghe He, Lian X. Liu, James Lister, Defne Kayrak-Talak Chapter 25 Advances in Process Controls and End-Point Determination, Kevin A. Macias, M. Teresa Carvajal   Chapter 26 Use of Artificial Intelligence and Expert Systems in Pharmaceutical Applications, Metin Çelik Chapter 27 Regulatory Issues in Granulation: Leading Next Generation Manufacturing, Prasad Kanneganti Chapter 28 QbD and PAT in Granulation, Shivang Chaudhary

Dilip M. Parikh is President, DPharma Group Inc., Ellicott City, Maryland, USA. As a Chemical and pharmaceutical engineer, he has more than 45 years of experience in product developments and manufacturing, process engineering, operational management of various pharmaceutical facilities in Canada and the USA. He is an invited speaker globally on various solid dosage manufacturing technologies and troubleshooting, process optimization strategies, regulatory remediation, and PAT & QbD implementation strategies. The author of many scientific journal articles, book chapters, and the editor of first, the second and third edition of Handbook of Pharmaceutical Granulation Technology.