Introduction
Disease overview
Epidemiology
Etiology and pathogenesis
Environmental factors
Genetic susceptibility
Role of humoral and cell-mediated immunity
Pathogenesis of systemic arthritis
Pathophysiology of macrophage activation syndrome
Disease classification
Classification criteria
Challenges in classification
Clinical manifestations
Systemic arthritis
Rheumatoid factor-negative polyarthritis
Rheumatoid factor-positive polyarthritis
Oligoarthritis
Enthesitis-related arthritis
Psoriatic arthritis
Undifferentiated arthritis
Diagnosis
Clinical assessment
Imaging
Biomarkers
Differential diagnosis
Consequences and complications
Disease course of different subtypes
Skeletal and growth abnormalities
Ophthalmologic complications
Macrophage activation syndrome
General treatment aspects
Goals of treatment
Measuring treatment response
Treatment recommendations
A multidisciplinary approach to treatment
Special considerations in the pediatric patient
Management of patients with
juvenile
idiopathic arthritis Psychosocial factors
Physical therapy
Other non-pharmacologic interventions
Non-steroidal anti-inflammatory drugs
Intra-articular corticosteroids
Systemic corticosteroids
Conventional disease-modifying anti-rheumatic drugs
Biologic disease-modifying anti-rheumatic drugs
Safety of biologics
Other pharmacologic interventions
Management of iridocyclitis
Management of macrophage activation syndrome
Specific issues
Health-related quality of life
Vaccination
Treatment discontinuation after disease remission
Transition to adult care
Outcome, prognosis and future outlook
Long-term outcome and its prediction
Mortality
Future outlook
