Fundamentals of Inflammation

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Part I: 1. Acute inflammation and chronic inflammation Peter Ward; 2. Resolution of acute inflammation and wound healing Derek W. Gilroy; 3. Links between innate and adaptive immunity Christopher L. Karp; Part II. Individual Cell Types: 4A. Neutrophils I Jose U. Scher, Steven B. Abramson and Michael H. Pillinger; 4B. Neutrophils II Marco A. Cassatella; 5. Mast cells as sentinels of inflammation Joshua A. Boyce; 6. Basophils Jonathan Arm and David Sloane; 7. Eosinophils Sophie Fillon, Steven J. Ackerman and Glenn T. Furuta; 8. Macrophages Sarah Fox and Adriano G. Rossi; 9. Lymphocytes Tracy Hussell; 10. Fibroblasts and stromal cells Andrew Filer and Christopher D. Buckley; 11. Cell-cell interactions: PMN endothelial cells János G. Filep and Sean Colgan; Part III. Chemical Mediators: 12. Lipid mediators in acute inflammation and resolution: eicosanoids, PAF, resolvins and protectins Charles Serhan and Jesper Z. Haeggström; 13. Cytokines and chemokines / IL-1 family in inflammation Nick Lukacs; 14. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases György Haskó and Bruce Cronstein; 15. Leukocyte generation of reactive oxygen species William Nauseef; 16. Cell adhesion molecules Lucy V. Norling, Giovanni Leoni, Dianne Cooper and Mauro Perretti; Part IV. Immunopharmacology: 17. Mediators and mechanisms of inflammatory pain Tony L. Yaksh; 18. Non-steroidal anti-inflammatory drugs Roderick Flower and Samir S. Ayoub; 19. Cytokines and chemokines in inflammation cancer Thorsten Hagemann and Toby Lawrence; Part V. Inflammatory Diseases/Histology: 20. Lung Bruce D. Levy; 21. Neural inflammation, Alzheimer's disease and stroke Andrew P. Lieberman and Constance D'Amato; 22. Rheumatoid arthritis/SLE Karim Raza and Caroline Gordon; 23. Gastrointestinal inflammation and ulceration: mediators of induction and resolution Linda Vong, Paul L. Beck and John Wallace; 24. Inflammatory skin diseases Gayathri K. Perera and Frank Nestle; 25. Kidney glomerulonephritis and renal ischemia Jeremy Duffield and Joel Henderson; 26. Inflammation in cardiovascular diseases Kenneth K. Wu; Part VI. Animal Models of Inflammation: 27. Models of acute inflammation – air-pouch, peritonitis and ischemia-reperfusion André L. F. Sampaio, Neil Dufton and Mauro Perretti; 28A. Experimental models of glomerulonephritis Aidan Ryan, Denise M. Sadlier and Catherine Godson; 28B. Ischemia reperfusion injury and glomerulonephritis Jeremy Duffield; 29. Asthma Bruce D. Levy; 30. Arthritis Mike Seed; 31. Ocular inflammation models Karsten Gronert; 32. Atherosclerosis in experimental animal models Aksam Merched and Lawrence Chan; 33. Oral inflammation and periodontitis Alpdogan Kantarci, Hatice Hasturk and Thomas E. Van Dyke; 34. Pathogens and inflammation Fabiana S. Machado and Julio Aliberti; 35. Diabetes Michael J. Clare-Salzler.

Acute inflammatory response is the body's first alarm signal directed at containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many diseases. Fundamentals of Inflammation presents an introduction to cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Charles N. Serhan, PhD, is the Simon Gelman Professor of Anesthesia at Brigham and Women's Hospital, Director of the Center for Experimental Therapeutics and Reperfusion Injury, and Professor of Biochemistry and Molecular Pharmacology at Harvard Medical School, Cambridge, Massachusetts. He is one of the world's top researchers on inflammation and mediation.
Peter A. Ward, MD, is Stobbe Professor of Pathology at the University of Michigan Health Systems, Ann Arbor, Michigan. Dr Ward is past President of the United States and Canadian Academy of Pathology.
Derek W. Gilroy, PhD, is a lecturer in the Centre for Clinical Pharmacology, University College London, United Kingdom. He has received the Bayer Aspirin Prize and is a Wellcome Trust Research Career Development Fellow.