Functional and Molecular Glycobiology

Functional and Molecular Glycobiology provides a comprehensive introduction to the study of carbohydrates and their roles in the life sciences. The book explains the chemistry of carbohydrates, and the biosynthesis and diversity of different types of glycans. It looks at the functional role of glycoconjugate compounds in normal cellular processes, both in disease and development. The book also describes how these compounds can be studied, analyzed and manipulated for use in biotechnology.

Functional and Molecular Glycobiology explains the chemistry of carbohydrates, and the biosynthesis and diversity of different types of glycans. It looks at the functional role of glycoconjugate compounds in normal cellular processes, in both disease and development. The book also describes how these compounds can be studied, analysed and manipulated for use in biotechnology. Functional and Molecular Glycobiology is a unique introduction to the field bridging the gap between introductory books and current research.

Ch 1. An introduction to carbohydrate chemistry. Ch 2. Enzymes of glycosylation - the glycosyltransferases. Ch 3. Polysaccharides. Ch 4. N-linked glycoproteins. Ch 5. O-linked (mucin-type) glycoproteins. Ch 6. O-glcnac glycosylation of nuclear and cytosolic proteins. Ch 7. Species specific and unusual types of glycoprotein glycosylation. Ch 8. Glycoconjugates of the extracellular matrix of animals. Ch 9. Glycosphingolipids. Ch 10. Glycan chain extension and some common and important glycan structures. Ch 11. Sialic acids. Ch 12. Glycosylphosphatidylinositol (gpi)-anchored proteins. Ch 13. Carbohydrate-binding proteins (lectins). Ch 14. Tools for carbohydrate analysis. Ch 15. Modulation of glycan expression using inhibitors of N- and O-linked glycoconjugate processing, and transgenic technology. Ch 16. Disease processes in which carbohydrates are involved. Ch 17. Carbohydrate-based therapeutics. Ch18. Carbohydrate biotechnology.

Dr SusanBrooks, Dr M Dwek, Udo Schumacher