From Molecule to Men Molecular Basis of Congenital Cardiovascular Disorders

From molecule to man: Medical research has indeed taken this direction, and major improvements of our understanding of the pathophysiology and epidemiology of disease have been achieved. The molecular basis of the congenital cardiovascular disorders has been extended from relatively few congenital malformations into everyday illnesses such as diabetes mellitus, hyperlipoproteinaemea, and arterial hypertension. The monogenic and, more difficult, polygenic basis for a vast majority of cardiovascular disorders are being defined more precisely from year to year. This book gives an overview of what has been achieved so far and defines the current position.

Molecular Basis of Congenital Cardiovascular Disorders.- Genetics of dilated cardiomyopathy.- Registry of families with inherited dilated cardiomyopathy for molecular analyses.- Distinct phenotype patterns of Ca2+ handling proteins in end-stage failing human hearts.- Apoptosis in the overloaded myocardium: potential stimuli and modifying signals.- Analysis of inherited causes of hypertrophic cardiomyopathy as part of clinical practice.- Molecular genetics of arrhythmogenic right ventricular cardiomyopathy.- Cardiomyopathy: Genetics in muscular dystrophies.- Molecular impact of ion channel mutations for the pathogenesis of long-QT (LQT) syndromes.- Acquired abnormal QT prolongation and torsade de pointes — clinical significance of genetic information from congenital long QT syndrome.- Molecular genetic approaches to human hypertension.- Renin-angiotensin system and coronary artery disease — Interaction of angiotensin II with pro-inflammatory cytokines in human stable and unstable coronary plaques.- Genetics of Lipoprotein(a).- The molecular mechanisms of inherited hypercholesterolemia.- Insulin resistance: A pathogenic link between cardiovascular risk factors and atherosclerosis.- Genetic control of hemostatic factors in relation to atherosclerosis.- Increased platelet aggregability associated with platelet GPIIIa PIA2 polymorphism: the Framingham Offspring Study.- Genetic aspects of chronobiologic rhythms in cardiovascular disease.- Is capillary sprouting enough?.- Angiogenesis and gene therapy.- Genetic engineering for human bypass vein grafts.- Molecular cardiology and physician.