Essentials of Restenosis For the Interventional Cardiologist

Leading interventional cardiologists, including Patrick Serruys, Eric Topol, David Holmes, Thomas Luscher and others provide the gold-standard reference on the treatment of restenosis (coronary artery blockage) for interventional cardiologists. Dr. Serruys, who pioneered the use of drug-eluting stents, and other pioneers in the field cover everything from non-invasive imaging, to eluting stents, to brachytherapy through to the latest molecular biology-based treatments including antisense, stem cells and gene therapy, making this an essential reference for all interventional cardiologists.

Pathophysiology and Diagnosis.- Unraveling the Complex Process of Restenosis From Bench to Bedside.- Epidemiology and Pathogenesis of Restenosis.- Clinical Presentation of Restenosis.- Pathological Anatomy of Restenosis.- The Influence of Shear Stress on Restenosis.- The Immune System in the Pathogenesis of Vascular Proliferative Disease.- Animal Restenosis Models.- Genetic Basis of Restenosis.- The Genomics of Restenosis.- Gene-Expression Profiling and Restenosis.- Proteomics and Restenosis.- Contribution of Circulating Progenitor Cells to Vascular Repair and Lesion Formation.- Cell Cycle Regulators and Vascular Proliferative Diseases.- Arterial Remodeling.- The Role of eNOS in Vascular Diseases.- Diagnosis of Restenosis.- The Use of Pressure Gradient in the Diagnosis of Restenosis.- The Use of Radio Isotopes in the Diagnosis of Vascular Proliferative Disease.- Magnetic Resonance Imaging for Restenosis.- Coronary Imaging With Multislice Spiral Computed Tomography.- Therapy of Restenosis.- Pharmacotherapy of Restenosis.- Brachytherapy.- Preclinical Data of Eluting Stents.- Clinical Data of Eluting Stents.- Biodegradable Stents.- Biotechnology in the Treatment of Restenosis.- Vascular Gene Therapy.- Antisense and ODN Transcription Factors in the Treatment of Vascular Proliferative Disease.- Cell Cycle Approaches to the Treatment of In-Stent Restenosis.- Local Gene and Cell Delivery Devices.