Drug Toxicity and Metabolism in Pediatrics

The aim of this text is to examine the physiological development of the fetus. It allows the reader to study the unique pharmacokinetic and metabolic features of newborns and gives specific examples of drug metabolism in the newborn. The purpose of this book is to enhance the current knowledge of pharmacology of the newborn by observing the embryo and placenta in normal and abnormal development, placental transfer of drugs, metabolic pathways, and metabolism of specific drugs such as theophylline, benzodiazepines, and antibiotics. This is a useful book for those involved in pediatric research, pharmacology, toxicology, experimental therapeutics and biology.

1. Developmental Aspects of Pediatric Pharmacology and Toxicology 2. Fetal and Neonatal Drug Biotransformation 3. Effects of Cisplatin on the Chick Embryo 4. A Model for the Analysis of Prenatal Toxicity 5. Pharmacology of Catecholamines 6. Antidysrhythmic Drugs in Pediatrics 7. Diagnosis and Management of Hypertension in Pediatrics 8. Pharmacology and Toxicology of Loop Diuretics in Pediatrics 9. Chloramphenicol 10. Developmental Pharmacology of Aminoglycosides and Vancomycin 11. Toxicity of Antineoplastic Chemotherapy in Children 12. Barbiturate and Non-Barbiturate Sedative Hypnotic Intoxication: An Overview 13. The Role of Doxapram in Pediatrics 14. Metabolism and Toxicity of Antiprostaglandin Agents 15. Pharmacological and Toxicological Aspects Associated with H1 Receptor Antagonists 16. Drugs in Gastrointestinal Disorders in Developing Infants 17. Iron Poisoning.