Drug Discovery and Development

Overview.- Drug Discovery and Development: Reflections and Projections.- Compound Discovery.- Drug Design.- Computer-Based Approaches to Drug Design.- Use of Intact Tissue Preparations in the Drug Discovery Process.- Neuropsychopharmacological Drug Development.- Biochemical Approaches for Evaluating Drug—Receptor Interactions.- Drug Discovery at the Enzyme Level.- EEG, EEG Power Spectra, and Behavioral Correlates of Opioids and Other Psychoactive Agents.- Immunopharmacological Approaches to Drug Development.- Toxicological Evaluation and Clinical Aspects.- Toxicological Evaluation of Drugs.- Drug Delivery Systems.- Clinical Evaluation of Drug Candidates.- Therapeutic Entities—From Discovery to Human Use.- Cimetidine and Other Histamine H2-Receptor Antagonists.- Atypical Psychotropic Agents: Trazodone and Buspirone.- Calcium Channel Antagonists.