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brunschweiger andreas (curatore); young damian w. (curatore) - dna-encoded libraries

DNA-Encoded Libraries


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Lingua: Inglese


Pubblicazione: 11/2022
Edizione: 1st ed. 2022


This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening (HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. 

The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as to graduate students and scholars who are interested in this rapidly improving technology.


A History of Selection-Based High-Throughput Screening Technologies for Hit Identification.- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical
Libraries.- Advancements in DEL-Compatible Chemical Reactions.- Design Considerations in Constructing and Screening DNA-Encoded Libraries.- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries.- Selection Strategies in DNA-Encoded Libraries.- From DEL Selections to Validated Hits to Clinical Leads.- A Perspective on 30 Years of DNA-Encoded Chemistry.



Andreas Brunschweiger studied Pharmacy at the University of Kiel. He obtained his Ph.D. in Medicinal Chemistry at the University of Bonn. Following postdoctoral stays at the University of Bonn, and at ETH Zurich, he is currently heading a group at TU Dortmund University. His research interests include DNA-encoded library technology, library design, screening, methods for data analysis, and medicinal chemistry.

Damian W. Young received a B.S. degree in chemistry (with ACS Certification) from Howard University. He then spent a year working as a process chemist on the anti-HIV drug Fuzeon at Trimeris Inc. before earning a Ph.D. in organic chemistry from North Carolina State University. Following this, he conducted a postdoctoral fellowship at Harvard University and the Broad Institute of MIT and Harvard.  He became a Group Leader within the Chemical Biology Program at the Broad. Dr Young is currently the Associate Director for the Center for Drug Discovery at Baylor College of Medicine and a faculty member within the Department of Pharmacology and Chemical Biology. His research is focused on the application of diversity-oriented synthesis to DNA encoded chemistry technology and fragment-based drug discovery.

Altre Informazioni



Condizione: Nuovo
Collana: Topics in Medicinal Chemistry
Dimensioni: 235 x 155 mm Ø 600 gr
Formato: Copertina rigida
Illustration Notes:IX, 276 p.
Pagine Arabe: 276
Pagine Romane: ix

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