Dietary Polyphenols in Human Diseases Advances and Challenges in Drug Discovery

Diets rich in plant polyphenols or dietary polyphenols are the subject of increasing scientific interest because oftheirdiverse range of health benefits and medicinal uses. This book, Dietary Polyphenols in Human Diseases: Advances and Challenges in Drug Discovery, fills the gap that exists in the current knowledge by presenting the latest information in the area of polyphenol-based drug discovery research. The book focuses on the current understanding of the beneficial effects on human healthof diets rich in polyphenols and/or polyphenolic compounds derived from dietary sources (plant-based foods) and their possible preventive role in the management of chronic human diseases. In addition, biochemical mechanisms involved in the antioxidative effect of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations are also discussed herein. Key Features Presents health benefits and medicinal importance of dietary polyphenols having antioxidative effects and their possible preventive role against oxidative stress (OS)-induced chronic human diseases. Summarizes thelatest understanding of the biochemical mechanism(s) involved in the antioxidative action of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations. Highlights novel approaches of drug discovery from dietary polyphenols through computational screening of bioactive phytochemical components. Withcontributions by a global team of experts (academics, scientists, and researchers), this book is intended to be a useful resourcefor a wider audience, particularly those working in the area of drug discovery and development research, such as discovery scientists, pharmaceutical scientists (R&D), formulation scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, clinicians, researchers, students, teachers, and many others.

Chapter 1: Dietary Polyphenols, Antioxidant Effects, and Human Diseases Himadri Kalita, Prashanta Kumar Deb, Rajdeep Saha, Amrita Chatterjee, Suparna Roy Sarkar, Satish Kumar, and Biswatrish Sarkar Chapter 2: Biochemical, Molecular, Pharmacokinetic, and Toxicological Aspects of Dietary Polyphenols Yousef Rasmi, Aline Priscilla Gomes da Silva, Sahar Rezaei, Safa Rafique, and Muhammad Zeeshan Ahmed Chapter 3: Dietary Polyphenols in Aging, Neurological, and Cognitive Disorders Lalit Mohan Nainwal and Poonam Arora Chapter 4: Dietary Polyphenols in Cancer Ashish Shah, Vaishali Patel, and Ghanshyam Parmar Chapter 5: Dietary Polyphenols in Cardiovascular Diseases (CVDs) Johra Khan and Mithun Rudrapal Chapter 6: Dietary Polyphenols in Arthritis and Inflammatory Disorders Lalit Mohan Nainwal and Poonam Arora Chapter 7: Dietary Polyphenols in Diabetes Yousef Rasmi, Safa Rafique, Quratulain Babar, Behrokh Daei-Hasani, and Yeganeh Farnamian Chapter 8: Dietary Polyphenols in Bacterial and Fungal Infections Veda Joshi, Swarangi Tambat, Mustansir Bhori, Jyotirmoi Aich, and Kanchanlata Tungare Chapter 9: Dietary Polyphenols in Viral Infections Vishal K. Singh, Jayati Dwivedi, Aditya K. Yadav, and Ramendra K. Singh Chapter 10: Dietary Polyphenols in Parasitic Diseases and Neglected Tropical Diseases (NTDs) James H. Zothantluanga, Arpita Paul, Ngurzampuii Sailo, Zonunmawii, H. Lalthanzara, and Dipak Chetia Chapter 11: Dietary Polyphenols for the Management of Skin Diseases and Wound Healing Shiv Kumar Prajapati, Dolly Jain, Sapna Joshi, Payal Kesharwani, and Siddhartha Maji Chapter 12: Dietary Polyphenols from Spice and Their Impact on Human Health Neelesh Kumar Nema, Nayana Rajan, Merin Babu, Sachithra Sabu, Swapnil Devidas Khamborkar, Smitha Sarojam, Linson Cheruveettil Sajan, Aneena Peter, Baby Kumaranthara Chacko, and Viju Jacob Chapter 13: Dietary Polyphenols in Drug Discovery by Drug Repurposing and Computational Screening Ipsa Padhy, Aastha Mahapatra, Fahima Dilnawaz, and Tripti Sharma

Mithun Rudrapal, PhD, FIC, is Associate Professor and Head at the Department of Pharmaceutical Chemistry, Rasiklal M. Dhariwal Institute of Pharmaceutical Educationand Research (affiliatedwith Savitribai Phule Pune University), Pune, Maharashtra, India. Dr. Rudrapal works in Medicinal Chemistry, CADD, Drug Repurposing, Phytochemistry, Herbal Drugs, and Nanophytotherapeutics.