What Is Data-Intensive Science?, Terence Critchlow and Kerstin Kleese van Dam Where Does All the Data Come From?, Geoffrey Fox, Tony Hey, and Anne Trefethen Data-Intensive Grand Challenge Science ProblemsLarge-Scale Microscopy Imaging Analytics for In Silico Biomedicine, Joel Saltz, Fusheng Wang, George Teodoro, Lee Cooper, Patrick Widener, Jun Kong, David Gutman, Tony Pan, Sharath Cholleti, Ashish Sharma, Daniel Brat, and Tahsin Kurc Answering Fundamental Questions about the Universe, Eric S. Myra and F. Douglas Swesty Materials of the Future: From Business Suits to Space Suits, Mark F. Horstemeyer Case StudiesEarth System Grid Federation: Infrastructure to Support Climate Science Analysis as an International Collaboration: A Data-Driven Activity for Extreme-Scale Climate Science, Dean N. Williams, Ian T. Foster, Bryan Lawrence, and Michael Lautenschlager Data-Intensive Production Grids,Bob Jones and Ian Bird EUDAT: Toward a Pan-European Collaborative Data Infrastructure, D. Lecarpentier, J. Reetz, and P. Wittenburg From Challenges to SolutionsInfrastructure for Data-Intensive Science: A Bottom-Up Approach, Eli Dart and William Johnston A Posteriori Ontology Engineering for Data-Driven Science, Damian D.G. Gessler, Cliff Joslyn, and Karin Verspoor Transforming Data into the Appropriate Context, Bill Howe Bridging the Gap between Scientific Data Producers and Consumers: A Provenance Approach, Eric G. Stephan, Paulo Pinheiro, and Kerstin Kleese van Dam In Situ Exploratory Data Analysis for Scientific Discovery, Kanchana Padmanabhan, Sriram Lakshminarasimhan, Zhenhuan Gong, John Jenkins, Neil Shah, Eric Schendel, Isha Arkatkar, Rob Ross, Scott Klasky, and Nagiza F. Samatova Interactive Data Exploration, Brian Summa, Attilay Gyulassy, Peer-Timo Bremer, and Valerio Pascucci Linked Science: Interconnecting Scientific Assets, Tomi Kauppinen, Alkyoni Baglatzi, and Carsten Keßler Summary and Conclusions, Terence Critchlow and Kerstin Kleese van Dam Index