COVID-19 From Bench to Bedside

The COVID-19 pandemic has affected the entire world in an unprecedented way, and this book provides an overview of the historical facts as well as ongoing approaches to tackle the COVID-19 pandemic. Experts of the respective domains provide details on anti-SARS-CoV-2 drug strategies, including repurposing drugs used for other indications and the development of novel drugs looking at different approaches to target virus entry and replication. COVID-19 vaccine development based on inactivated and attenuated live virus, protein subunit and peptide-based vaccines and utilization of vaccine candidates based on viral vectors, DNA and RNA are presented for both preclinical studies and clinical trials. Key Features Explains the background of the COVID-19 pandemic, the current progress in the development of treatments and prevention of COVID-19 including future aspects of dealing with the pandemic Serves as a timely repository of knowledge on COVID-19 for researchers and medical professionals engaged in its management

Chapter 1 Coronavirus epidemics and the current COVID-19 pandemic Aparna Bhardwaj, Prateek Kumar, Shivani Krishna Kapuganti, Vladimir N. Uversky, and Rajanish Giri Chapter 2 Biology of Coronaviruses and Predicted Origin of SARS-CoV-2Giorgio Palù, Alberto Reale, Nicolas G. Bazan, Pritam Kumar Panda, Vladimir N. Uversky, Murat Seyran, Alaa A. A. Aljabali, Samendra P. Sherchan, Gajendra Kumar Azad, Wagner Baetas-da-Cruz, Parise Adadi, Murtaza M. Tambuwala, Bruce D. Uhal, Kazuo Takayama, Ángel Serrano-Aroca, Tarek Mohamed Abd El-Aziz1, Adam M. Brufsky and Kenneth Lundstrom Chapter 3 Therapeutic Challenges in COVID-19Alaa A. A. Aljabal1, Murtaza M. Tambuwala, Debmalya Barh and Kenneth Lundstrom Chapter 4 Prevention and Control Strategies for COVID-19 PandemicIsfendiyar Darbaz, Gizem Morris, and Sükrü Tüzmen Chapter 5 Global Focus and Interdisciplinary Approaches in COVID-19 Research and Their OutcomesHülya Senol and Sükrü Tüzmen Chapter 6 The evolution of COVID-19 diagnosticsPraveen Rai, Ballamoole Krishna Kumar, Deekshit Vijaya Kumar, Prashant Kumar, Anoop Kumar, Shashi Kumar Shetty and Biswajit Maitia Chapter 7 Drug repurposing and novel antiviral drugs for COVID-19 managementShailendra Dwivedi, Aakanksha Rawat, Amit Ranjan, Ruchika Agrawal, Radhieka Misra, Sunil Kumar Gupta, Surekha Kishore and Sanjeev Misra Chapter 8 Convalescent Plasma and Antibody Therapy in COVID-19Didem Rifki, Eymen Ü. Kiliç and, Sükrü Tüzmen Chapter 9 Application Stem Cell and Exosome Based Therapy in COVID-19Suleyman Gokhan Kara and Ayla Eker Sariboyaci Chapter 10 Host and Pathogen-Specific Drug Targets in COVID-19Bruce D. Uhal, David Connolly, Farzaneh Darbeheshti, Yong-Hui Zheng, Ifeanyichukwu E. Eke. Yutein Chung and Lobelia Samavati Chapter 11 Computational biology and bioinformatics in anti-SARS-CoV-2 drug developmentVladimir N. Uversky Chapter 12 Nanomaterials in COVID-19 drug developmentAlaa A A Aljabali, Ángel Serrano-Aroca and Murtaza M. Tambuwala Chapter 13 Vaccine Development Strategies and the Current Status of COVID-19 VaccinesMohsen Akbarian, Kenneth Lundstrom, Elrashdy M. Redwan and Vladimir N. Uversky Chapter 14 Clinical trials of COVID-19 therapeutics and vaccines: history, current status, and limitationsCandan Hizel Perry, Havva Ö. Kilgöz and Sükrü Tüzmen Chapter 15 Lessons Learned from COVID-19 and Their Implementations for Future PandemicsMauricio Corredor, Debmalya Barh and Kenneth Lundstrom

Dr. Debmalya Barh is currently a Visiting Full Professor (Titular, Grade-E) at the Department of Genetics, Ecology and Evolution, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Brazil. He is also an honorary Scientist at Institute of Integrative Omics and Applied Biotechnology (IIOAB), India. Dr. Kenneth Lundstrom is currently the CEO of PanTherapeutics in Lausanne, Switzerland.He serves on editorial boards of various journals including Biomedicines and Viruses, and acts as Editor-in-chief for Frontiers in Translational Virology.