Coronaviruses and other Novel Antiviral Targets

Annual Reports in Medicinal Chemistry, Volume 57 in this long-running series, highlights new advances in the field with this new volume presenting interesting chapters on the Mechanism of action of the broadly acting antiviral drug remdesivir, Improving properties of the nucleobase analogue T-706 as a potential anti-SARS-CoV-2 and anti-influenza compound, Antivirals for RNA virus infections Anno 2020-2021, Broad spectrum antiviral fleximer nucleosides, SARS-CoV-2 main protease inhibitors, The search for antivirals to treat alphavirus infections, Inhibitors of Ebola Virus targeting Innate immune evasion, Uracil derivatives as non-nucleoside inhibitors of viral infections, and more.

• Provides the authority and expertise of leading contributors from an international board of authors
• Presents the latest release in the Annual Reports in Medicinal Chemistry
• Updated release includes the latest information on the Coronaviruses and other novel antiviral targets

1. Improving properties of the nucleobase analogs T-705/T-1105 as potential antivirals

2. Anno 2021: Which antivirals for the coming decade?

3. Broad spectrum antiviral fleximer nucleosides

4. The search for antivirals to treat alphavirus infections

5. Inhibitors of Ebola Virus targeting Innate immune evasion

6. Uracil derivatives as non-nucleoside inhibitors of viral infections

Prof. Katherine Seley-Radtke group's NIH-funded research employs a chemical biology approach to
nucleoside, nucleotide and heterocyclic drug discovery and development with therapeutic
emphasis on antiviral, anticancer and antiparasitic targets and overcoming resistance to currently
used drugs. Current focus is targeting Ebola, Zika, Dengue and MERS viruses. She has served as
the Program Director for UMBC's Chemistry-Biology Interface graduate training program
funded by NIH since 2007. This program promotes hands on cross disciplinary research for
almost 50 PhD students from four departments at UMBC and UMB. She is currently the
Immediate Past President and Secretary-Elect for the International Society of Nucleosides,
Nucleotides and Nucleic Acids and a Board member of the International Society for Antiviral
Research. Prof. Seley-Radtke also serves as a standing member for several NIH study sections
and is an Associate Editor for three scientific journals - Antiviral Chemistry & Chemotherapy,
Molecules - Chemical Biology, and Current Protocols in Chemical Biology.