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This volume provides complete coverage of the computational approaches currently used in Synthetic Biology. Chapters focus on computational methods and algorithms for the design of bio-components, insight on CAD programs, analysis techniques, and distributed systems. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Authoritative and practical, Computational Methods in Synthetic Biology serves as a guide to plan in silico the in vivo or in vitro construction of a variety of synthetic bio-circuits.
Part I: Component Design
1. Computational Protein Design Methods for Synthetic Biology
Pablo Carbonell and Jean-Yves Trosset
2. Computer-Aided Design Of DNA Origami StructuresDenis Selnihhin and Ebbe Sloth Andersen
3. Computational Design Of RNA Parts, Devices, and Transcripts With Kinetic Folding Algorithms Implemented On Multiprocessor Clusters
Tim Thimmaiah, William E. Voje Jr., and James M. Carothers
4. Regulatory RNA Design Through Evolutionary Computation And Strand Displacement
William Rostain, Thomas E. Landrain, Guillermo Rodrigo, and Alfonso Jaramillo
Part II: Circuit Design
5. Programming Languages for Circuit Design
Michael Pedersen and Boyan Yordanov
6. Kappa Rule-Based Modelling in Synthetic Biology
John Wilson-Kanamori, Vincent Danos, Ty Thomson, and Ricardo Honorato-Zimmer
7. Modular Design Of Synthetic Gene Circuits With Biological Parts and Pools
Mario Andrea Marchisio
8. Computationally Guided Design Of Robust Gene Circuits
Najaf A. Shah and Casim A. Sarkar
9. Chemical Master Equation Closure for Computer-Aided Synthetic Biology
Patrick Smadbeck and Yiannis N. Kaznessis
10. Feedback loops in biological networks
Elisa Franco and Kate E. Galloway
Part III: Circuit Analysis and Simulations
11. Efficient Analysis Methods in Synthetic Biology
Curtis Madsen, Chris Myers, Nicholas Roehner, Chris Winstead, and Zhen Zhang
12. Using Computational Modeling and Experimental Synthetic Perturbations to Probe Biological Circuits
Joshua R. Porter and Eric Batchelor
13. In Silico Control Of Biomolecular Processes
Jannis Uhlendorf, Agnès Miermont, Thierry Delaveau, Gilles Charvin, François Fages, Samuel Bottani, Pascal Hersen, and Gregory Batt
14. Stochastic Modular Analysis For Gene Circuits: Interplay Among Retroactivity, Nonlinearity, and Stochasticity
Kyung Hyuk Kim and Herbert M Sauro
Part IV: Distributed Systems and Automation
15. Distributed Model Construction with Virtual Parts
Michael T. Cooling and Tommy Yu
16. The Synthetic Biology Open Language
Chris Myers, Kevin Clancy, Goksel Misirli, Ernst Oberortner, Matthew Pocock,
Jacqueline Quinn, Nicholas Roehner, and Herbert Sauro
17. Computational Methods For The Construction, Editing, and Error Correction Of DNA Molecules And Their Libraries
Ofir Raz and Tuval Ben Yehezkel
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