Computational Bioengineering

Arguably the first book of its kind, Computational Bioengineering explores the power of multidisciplinary computer modeling in bioengineering. Written by experts, the book examines the interplay of multiple governing principles underlying common biomedical devices and problems, bolstered by case studies. It shows you how to take advantage of the latest computational capabilities to deal with biomedical problems using an integrative approach. This approach fosters an integrative problem-solving mentality for the generation of new and novel solutions to future biomedical problems. Each chapter begins with a brief review of the advances in computational efforts in the selected topic area and ends with case studies with detailed technical information. The approach provides a relevant overview of the selected topic area and demonstrates, with case studies, the power of computational modeling in offering predictive capabilities to assess new surgical concepts and medical devices and post-operative surgical outcomes. The book illustrates the expanded capabilities of computational bioengineering through discussions of bioengineering problems and discusses an image-based bioengineering modeling technique. Although computer modeling has been used to tackle bioengineering problems for decades, a systematic study of computational bioengineering not only addresses many critical challenges facing bioengineering but also sets a new direction for advancing the field. In a long run, this book is expected to foster an integrative problem-solving mentality that will help you generate new and novel solutions to future biomedical problems.

An Integrative Way of Solving Bioengineering ProblemsGuigen ZhangToward Predicting the Performance of Joint ArthroplastyClare K. Fitzpatrick, Melinda Harman, Mark A. Baldwin, Chadd W. Clary, Lorin P. Maletsky, Peter J. Laz, and Paul J. RullkoetterMathematical Modelling of Basic Multicellular Units: The Functional Units of Bone RemodelingPascal R. Buenzli and Peter PivonkaEffect of Nonlinearity in Tensioned Wires of an External Fixation DeviceGuigen ZhangViscoelasticity of Load-Bearing Soft Tissues: Constitutive Formulation, Numerical Integration, and Computational ImplementationChristian M. Puttlitz, Snehal S. Shetye, and Kevin L. TroyerPhysical Signals and Solute Transport in Human Intervertebral Disc: Multiphasic Mechano-Electrochemical Finite Element AnalysisYongren Wu, Sarah E. Cisewski, and Hai YaoMultiscale Modeling of Cardiovascular FlowsAlison L. Marsden and Ethan KungComputational Fluid Modeling of Heart ValvesManuel Salinas and Sharan RamaswamyMathematical Modeling of Cancer MetastasesMarc D. Ryser and Svetlana V. KomarovaDynamic Processes in Photodynamic TherapyTimothy C. Zhu, Baochang Liu, and Michele M. KimComputational Cell Phenotyping in the Lab, Plant, and ClinicRahul Rekhi, David T. Ryan, Becky Zaunbrecher, Chenyue W. Hu, and Amina A. QutubMolecular Simulation of Protein-Surface InteractionsXianfeng Li and Robert A. LatourStructure of the Electrical Double Layers: Insights from Continuum and Atomistic SimulationsGuang Feng, Guoqing Hu, Rui Qiao, and Narayana R. AluruA Solid-State Nanopore as BiosensorSamuel Bearden and Guigen ZhangDNA Electrokinetic Translocation through a NanoporeShizhi Qian and Li-Hsien YehDielectrophoresis for Bioengineering Applications and Some Associated IssuesYu Zhao, Vandana Pandian, Johnie Hodge, Jozef Brcka, Jacques Faguet, and Guigen ZhangImage-Based Modeling for Bioengineering ProblemsAdrienne M. Madison and Mark A. Haidekker