CNS Drug Development and Delivery Concepts and Applications

The book covers recent advances in the field of CNS therapeutics, including opportunities posed by expanding basic knowledge related to CNS conditions  and novel approaches for efficient drug delivery to the brain (e.g., pharmaceutical nanocarriers and transporter- and transcytosis-mediated drug delivery to the brain inhibition of the blood-brain barrier). Chapters dealing with state-of-the-art in silico and in vitro tools for predictive purposes related to CNS bioavailability are also be included.

This is an ideal book for undergraduate students and graduates in the field of medicine and pharmaceutics, and professionals working in the field of brain disorders.

Chapter 1- Transporter-mediated drug delivery to the brain.- Chapter 2 - Mechanisms and methods for evaluating drug delivery via transcytosis to the brain.- Chapter 3 -In vitro blood-brain studies.- Chapter 4 - In silico prediction of CNS bioavailability.- Chapter 5 - Use of unbound exposure data to establish in vitro-in vivo correlations for CNS drug candidates.- Chapter 6 - Intranasal Delivery of Drugs to the Central Nervous System.- Chapter 7 - Polymeric nanoparticles for nose-to-brain delivery in Alzheimer's and Parkinson´s diseases.- Chapter 8 - Barriers of the CNS and their contribution to drug-resistant epilepsy.- Chapter 9 - Network-pharmacology and central nervous system drug development.

Prof. Alan Talevi was born in Buenos Aires, 1980. He obtained his Pharmacy degree in 2004 and completed his PhD studies in 2007, both at the University of La Plata (UNLP, Argentina). Among other recognitions, he obtained the award for the best PhD thesis on Computational Chemistry from the Argentinean Chemical Society (2008), a Pacifichem Young Scholar Award (USA, 2010) and the Award to Scientific and Technological Production from UNLP (2016). Since 2010, he holds a permanent position at the Argentinean Council of Scientific and Technical Research (CONICET), where he currently occupies a Principal Researcher position, and he is a Full Professor (tenured) in charge of the Biopharmacy/Pharmacokinetics course at the Faculty of Exact Sciences, UNLP. He has published over 100 articles in periodicals and more than 80 book chapters/entries, mostly in the fields of machine learning, drug discovery and biopharmaceutics.