Clinical Epidemiology - Parfrey Patrick S. (Curatore); Barrett Brendan J. (Curatore) | Libro Humana 04/2021 -

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parfrey patrick s. (curatore); barrett brendan j. (curatore) - clinical epidemiology

Clinical Epidemiology Practice and Methods


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Lingua: Inglese


Pubblicazione: 04/2021
Edizione: 3rd ed. 2021


This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system.


Table of Contents…
Contributing Authors…
Part I Introduction
1.   On Framing the Research Question and Choosing the Appropriate Research Design
Patrick S. Parfrey and Pietro Ravani
2.   Bias in Clinical Research
Susan Stuckless and Patrick S. Parfrey
3.   Definitions of Bias in Clinical Research
Geoffrey Warden
4.   Research Ethics for Clinical Researchers
John D. Harnett
       5.  Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics Research
Daryl Pullman and Holly Etchegary
Part II Longitudinal Studies

6.   Longitudinal Studies 1: Determinants of Risk
Sean W. Murphy
7.   Longitudinal Studies 2: Modeling Data using Multivariate Analysis
Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey
8.   Longitudinal Studies 3: Data Modeling using Standard Regression Models and Extensions
Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey
9.   Longitudinal Studies 4: Matching Strategies to Evaluate Risk
Matthew T. James
10. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease
Navdeep Tangri and Claudio Rigatto
Part III Randomized Controlled Trials
11. Randomized Controlled Trials 1: Design
Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey
12. Randomized Controlled Trials 2: Analysis 
Robert N. Foley and Patrick S. Parfrey
13. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes 
Michelle M. Richardson and Klemens B. Meyer
14. Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life Studies
Robert N. Foley and Patrick S. Parfrey
15. Randomized Controlled Trials 5: Biomarkers and Surrogates/Outcomes
Claudio Rigatto and Brendan J. Barrett
16. Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies
Tom Greene
17. Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect
      Patrick S. Parfrey
 Part IV Other Clinical Epidemiology Methods
18. Evaluation of Diagnostic Tests
Brendan J. Barrett and John M. Fardy
19. Genetic Epidemiology of Complex Phenotypes
Darren D. O’Rielly and Proton Rahman

20. Qualitative Research in Clinical Epidemiology
Stephanie Thompson and Kara Schick-Makaroff 
Part V Methods in Evidence-Based Decision Making
21. Evidence Based Decision Making 1: Critical Appraisal 
Laurie K. Twells

22. Evidence Based Decision Making 2: Systematic Review and Meta-Analysis 
Aminu Bello, Ben Vandermeer, Natasha Wiebe, Amit X. Garg, and Marcello Tonelli

23. Evidence-Based Decision Making 3: Health Technology Assessment
Daria O’Reilly, Richard Audas, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree
24. Evidence-Based Decision Making 4: Clinical Practice Guidelines
      Tae Won Yi, Sine Donnellan, and Adeera Levin
25. Evidence-Based Decision Making 5: Knowledge Translation and the Knowledge to Action Cycle
Braden J. Manns
26. Evidence-Based Decision Making 6: Administrative Databases as Secondary Data Source for Epidemiologic and Health Service Research
Tanvir Turin Chowdhury and Brenda R. Hemmelgarn
27. Methods in Evidence-Based Decision Making 7: Health Economics in Clinical Research
Braden J. Manns 
28. Methods in Evidence-Based Decision Making 8: A Primer for Researchers
      Victor Maddalena and Maisam Najafizada 
 Part VI Changing Health-Related Behaviors
29. Changing Health-Related Behaviors 1: Patient-Oriented Research and Patient Engagement in Health Research
Catherine Street, Laurie K. Twells, Toni Leamon, Lynn Taylor, and Holly Etchegary
30. Changing Health-Care Behaviors 2: On Improving the Value of Health Spending
Karen Dickson, Robert Wilson, Owen Parfrey, and Patrick S. Parfrey
31. Changing Health-Related Behaviors 3: Lessons from Implementation Science
Amanda Hall, Helen Richmond, Krista Mahoney, and James Matthews
32. Changing Health-Related Behaviors 4: Realizing Impact of Health Research through Knowledge Translation
Kate Lambert, Krista Mahoney, and Patrick S Parfrey
33. Changing Health-Related Behaviors 5: On Interventions to Change Physician Behaviors
Cheryl Etchegary, Lynn Taylor, Krista Mahoney, Owen Parfrey, and Amanda Hall
34. Changing Health-Related Behaviors 6: Analysis, Interpretation, and Application of Big Data
Randy Giffen and Donald Bryant
Subject Index List…

Altre Informazioni



Condizione: Nuovo
Collana: Methods in Molecular Biology
Dimensioni: 254 x 178 mm Ø 1429 gr
Formato: Copertina rigida
Illustration Notes:53 Illustrations, black and white
Pagine Arabe: 650
Pagine Romane: xiii

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