Clinical Aspects of Electroporation

Electroporation is the forefront in tumor ablation. This book presents the basic principles and clinical applications of electroporation, including the latest research results and patient data. A comprehensive approach to the basic science behind the development of this ground-breaking technique and its introduction into clinical practice, the book discusses the entire spectrum of currently available reversible treatments, the emerging irreversible applications, and their impact on patient care. Clinical Aspects of Electroporation is the first book intended for clinicians on this extremely important and rapidly developing field.

Introduction to Electroporation.- Electroporation and cellular physiology.- The cell in the electric field.- Understanding Electric Fields for Clinical Use.- Generators and Applicators – Equipment for Electroporation.- Cell electropermeabilization and cellular uptake of small molecules: the electrochemotherapy concept.- Vascular-disrupting action of electrochemotherapy: mode of action and therapeutic implications.- Electrochemotherapy of small tumors; the experience from the ESOPE (European Standard Operating Procedures for Electrochemotherapy) group.- Electrochemotherapy for larger malignant tumors.- Cell electroporation in bone tissue.- Drug and Gene electrotransfer to the brain.- Minimally invasive intraluminal tumor ablation.- Electrotransfer of plasmid DNA.- Gene Electrotransfer to Tumor.- Gene electrotransfer to lung.- Gene electrotransfer to muscle tissue; moving into clinical use.- Gene electrotransfer to skin.- Electroporation-mediated DNA vaccination.- Irreversible Electroporation (IRE) on Liver Tumor Ablation: A Summary of Preclinical Translational Research.- Translational Research on Irreversible Electroporation – VX2 Rabbit Head and Neck.- Clinical Research on Irreversible Electroporation of the Liver