Circadian Rhythms, Sleep and Inflammation

The circadian clock is a complex cellular mechanism that controls numerous key physiological processes and maintains cellular, tissue, and systemic homeostasis. Disruption of the clock system influences the immune response and brain functions. Immune activation is closely linked with inflammation, neurodegeneration, aging, and other peripheral and central nervous system-related abnormalities. There is increasing evidence that cellular inflammation affects sleep and circadian rhythms and vice-versa. This book offers a structured overview that focuses on the multi-angle interaction of circadian rhythms, sleep, and inflammatory response in normal or pathological conditions.   

Circadian Regulation of Neuroinflammation.- Circadian Regulation of Peripheral Inflammation.- Sleep and Neuroinflammation.- Sleep and Circadian Rhythm in Peripheral Inflammation: Realm of Interconnected Frontiers.- Neuro-Inflammatory Response and Immune-Brain Crosstalk in Sleep Regulation.- Sleep and Circadian Disruption in Depression and Anxiety Disorders: An Inflammatory Insight.- Inflammatory Impact on Sleep, Shizophrenia, and Autism Spectrum Disorder.- Chronobiological Aspects of Aging, Neurodegeneration, and Inflammation.- Sleep, Aging, and Inflammation: Unravelling the Connections.

Dr. Pawan K. Jha is a PhD (Neuroscience) from the University of Amsterdam, the Netherlands, and the University of Strasbourg, France. As a post-doc at The Francis Crick Institute, London, UK, and the University of Pennsylvania, Philadelphia, PA, USA. Dr. Jha has worked with the molecular mechanism of sleep and circadian rhythms. He is serving as a review editor at Frontier of Neuroscience and guest editor at JOVE. 

Dr. Hanan Bouaouda is a veterinary doctor (DVM). She completed her PhD in Neuroscience at the University of Strasbourg, France, and Hassan II Institute of Agronomy and Veterinary Medicine, Rabat, Morocco. After her PhD, she worked on a variety of themes of sleep and circuitries at the International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Japan, and Harvard Medical School, Boston, USA. She is currently working on brain thermoregulatory circuits and their implications in metabolic abnormalities at Heidelberg University, Heidelberg, Germany. Dr. Bouaouda won several international awards (the Takeda International Fellowship Program awarded by the Takeda Science Foundation in Japan and The Eiffel Excellence scholarship program awarded by the French Ministry for Europe and Foreign Affairs).