Chemical Warfare Agents Chemistry, Pharmacology, Toxicology, and Therapeutics, Second Edition

Written by experts known for their contributions to the science of toxic chemicals, this comprehensive text gives professionals the latest information about the pathophysiology of chemical warfare agent injury at low concentrations.

The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater sense of urgency within the field of chemical defense since this event, research related to chemical warfare agents (CWAs) continues to expand at a remarkable pace. Chemical Warfare Agents: Pharmacology, Toxicology, and Therapeutics, Second Edition explores the latest methods and products for preventing, diagnosing, and treating the acute and chronic effects of toxic CWA exposure. This edition citesthe key developments in chemical defense research since 2001, including new epidemiological or clinical studies of exposed or potentially exposed populations; new treatment concepts and products; improved organization of the national response apparatus in the U.S. addressing the potential for CWA terrorism; and improved diagnostic tests that enable rapid diagnosis and treatment. Leading researchers explain how these breakthroughs help researchers determine physiologically relevant detection thresholds and develop more effective countermeasures and national response procedures. Chemical Warfare Agents provides first responders and emergency medical teams with the most up-to-date information they need to prepare for and handle natural disasters, chemical spills, terrorism, and warfare situations—quickly and effectively.

Brief History and Use of Chemical Warfare Agents in Warfare and Terrorism; H. Salem, A.L. Ternay Jr., and J.K. Smart The Chemistry of Chemical Warfare Agents; P. Kikilo, V. Fedorenko, and A.L. Ternay Jr. Chemical Warfare Agent Threat to Drinking Water; H. Salem, C.E. Whalley, C.H. Wick, T.P. Gargan II, and W.D. Burrows Health Effects of Low-Level Exposure to Nerve Agents; J.H. McDonough and J.A. Romano Jr. Toxicokinetics of Nerve Agents; M.J. van der Schans, H.P. Benschop, and C.E. Whalley Application of Genomic, Proteomic, and Metabolomic Technologies to the Development of Countermeasures Against Chemical Warfare Agents; J.W. Sekowski and J.F. Dillman Novel Approaches to Medical Protection Against Chemical Warfare Nerve Agents; A. Saxena, C. Luo, N. Chilukuri, D.M. Maxwell, and B.P. Doctor Nerve Agent Bioscavengers: Progress in Development of a New Mode of Protection Against Organophosphorus Exposure; D.E. Lenz, C.A. Broomfield, D.T. Yeung, P. Masson, D.M. Maxwell, and D.M. Cerasoli Butyrylcholinesterase and Its Synthetic C-terminal Peptide Confer In Vitro Suppression of Amyloid Fibrils Formation; E. Podoly, S. Diamant, A. Friedler, O. Livnah, and H. Soreq A Novel Medical Countermeasure for Organophosphorus Intoxication: Connection to Alzheimer’s Disease and Dementia; Edna F.R. Pereira, D.R. Burt, Y. Aracava, R.K. Kan, T.A. Hamilton, J.A. Romano Jr., M. Adler, and E.X. Albuquerque Inhalation Toxicology of Nerve Agents; P.A. Dabisch, S.W. Hulet, R. Kristovich, and R.J. Mioduszewski Vesicants and Oxidative Stress; M.G. Smith, W. Stone, R.F. Guo, P.A. Ward, S. Mukherjee, S.K. Das, and Z. Suntres Health Effects of Exposure to Vesicant Agents; C.G. Hurst and W.J. Smith Cyanides: Toxicology, Clinical Presentation, and Medical Management; B. Ballantyne and H. Salem Chemicals Used for Riot Control and Personal Protection; H. Salem, B. Ballantyne, and S. Katz Mechanism of Action of Botulinum Neurotoxin and Overview of Medical Countermeasure Development for Intoxication; M. Adler, G. Oyler, J.P. Apland, S.S. Deshpande, J.D. Nicholson, J. Anderson, C. Millard, and F.J. Lebeda Ricin and Related Toxins: Review and Perspective; C.B. Millard and R.D. LeClaire Screening Smokes: Applications, Toxicology, Clinical Considerations, and Medical Management; B. Ballantyne and H. Salem Clinical Detection of Exposure to Chemical Warfare Agents; B.R. Capacio, J.R. Smith, R.K. Gordon, J.R. Haigh, J. Barr, and B.J. Lukey Personal Protective Equipment (PPE): Practical and Theoretical Considerations; M.R. Jones Chemical Warfare Agent Decontamination from Skin; B.J. Lukey, H.F. Slife Jr., E. Clarkson, C.G. Hurst, and E.H. Braue Jr. Chemical Warfare, Chemical Terrorism, and Traumatic Stress Responses: An Assessment of Psychological Impact; J.A. Romano Jr., L. Lumley, J.M. King, and G.A. Saviolakis Emergency Response to a Chemical Warfare Agent Incident: Domestic Preparedness, First Response, and Public Health Considerations; D.H. Moore and B. Saunders-Price Emergency Medical Response to a Chemical Terrorist Attack; S.A. Pulley and M.R. Jones Index