Examining the chemical modification of biological polymers and the emerging applications of this technology, Chemical Modification of Biological Polymers reflects the change in emphasis in this subsection of biotechnology from the study of protein structure and function toward applications in therapeutics and diagnostics.
This book covers the basics on the organic chemistry underlying the chemical modification of biopolymers, including updates on the use of various chemical reagents. It describes the current status of chemical modification of biological polymers and emerging applications of this technology in biotechnology. These technologies are important for the manufacture of conjugate proteins used in drug delivery, for the preparation of nucleic acid microarrays, and for the preparation of hydrogels and other materials used in tissue engineering.
Functional groups in Biological Polymers and Factor Governing Reactivity
Identification of Functional Groups
Nucleophilicity and reactivity
Modification of Amino Groups in Proteins
Arginine (guanidine group)
Modification of Hydroxyl and Carboxyl Groups in Proteins
Modification of Imidazole and Indole Groups in Proteins
Modification of Sulfur-Containing Groups in Proteins
Modification of Nucleic Acids
Periodate oxidation (see under polysaccharides)
Modification of Polysaccharides
Periodate oxidation (Malaprade reaction)
In Vivo Non-enzymatic chemical modification of biological polymers
Proteomic Methods for the Analysis of the Modification of Biological Polymers
Chemical Methods for the Preparation of Conjugates of Biological Polymers
Protein-matrix (including protein microarrays)
Roger L. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his PhD in biochemistry at the University of Washington. After postdoctoral work in the laboratories of Stanford Moore and William Stein at The Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill. He joined the Hyland Division of Baxter Healthcare in 1990. Currently, Dr. Lundblad works as an independent consultant at Chapel Hill, North Carolina, and writes on biotechnological issues. He is also an adjunct professor of pathology at the University of North Carolina.
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