Chemical Biophysics Quantitative Analysis of Cellular Systems

Chemical Biophysics provides an engineering-based approach to biochemical system analysis for graduate-level courses on systems biology, computational bioengineering and molecular biophysics. It is the first textbook to apply rigorous physical chemistry principles to mathematical and computational modeling of biochemical systems for an interdisciplinary audience. The book is structured to show the student the basic biophysical concepts before applying this theory to computational modeling and analysis, building up to advanced topics and research. Topics explored include the kinetics of nonequilibrium open biological systems, enzyme mediated reactions, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems. End-of-chapter exercises range from confidence-building calculations to computational simulation projects.

Preface; Introduction; Part I. Background Material: 1. Concepts from physical chemistry; 2. Conventions and calculations for biochemical systems; 3. Chemical kinetics and transport processes; Part II. Analysis and Modeling of Biochemical Systems: 4. Enzyme-catalyzed reactions; 5. Biochemical signaling modules; 6. Biochemical reaction networks; 7. Coupled biochemical systems and membrane transport; Part III. Special Topics: 8. Spatially distributed systems and reaction-diffusion modeling; 9. Constraint-based analysis of biochemical systems; 10. Biomacromolecular structure and molecular association; 11. Stochastic biochemical systems and the chemical master equation; 12. Appendix: the statistical basis of thermodynamics; Bibliography; Index.

Chemical Biophysics provides an engineering-based approach to biochemical system-analysis for graduate level courses on systems biology, computational bioengineering and molecular biophysics. It was the first textbook to apply rigorous physical chemistry principles to mathematical and computational modelling of biochemical systems for an interdisciplinary audience.