Chemical Biology of Natural Products

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

Chapter 1: Microbial Genome Mining for Natural Product Drug Discovery Chapter 2: Chemical Biology of Marine Cyanobacteria Chapter 3: The Role of Combinatorial Biosynthesis in Natural Products Discovery Chapter 4: The Generation of New to Nature Natural Products Through Synthesis and Biosynthesis: Blending Synthetic Biology with Synthetic Chemistry Chapter 5: Terrestrial Microbial Natural Products Discovery Guided by Symbiotic Interactionsand Revealed by Advanced Analytical Methods Chapter 6: Natural Products from Endophytic Microbes. Historical Perspectives, Prospects, and Guidance Chapter 7: Novel Insights in Plant Endophyte Interactions Chapter 8: Microbial Co-culture and OSMAC Approach as Strategies to Induce Cryptic FungalBiogenetic Gene Clusters Chapter 9: Natural Products of the Rhizosphere and Its Microorganisms: Bioactivities and Implications of Occurrence Chapter 10: Novel Metabolites from Extremophilic Microbes Isolated from Toxic Waste Sites Chapter 11: Deep-Sea Hydrothermal Vent Organisms as Sources of Natural Products Chapter 12: Cone Snail Venom Peptides and Future Biomedical Applications of Natural Products Chapter 13: Naturally Occurring Disulfide-rich Peptides from Plants and Animals: Synthesis andBiosynthesis Chapter 14: Synthesis and Target Identification of Natural Product Inspired Compound Collections Chapter 15: On The Chemistry and Biology of the Marine Macrolides Zampanolide and Dactylolide

David J. Newman retired from the position of chief of the Natural Products Branch (NPB) in the Developmental Therapeutics Program at the National Cancer Institute (NCI) in Frederick, Maryland, in early January 2015. He is the author or coauthor of over 180 papers, reviews, and book chapters (and an editor, with Gordon M. Cragg and David Kingston, of Anticancer Agents from Natural Products), andholds 18 patents, mainly on microbial products. He is still associated with the NPB/NCI as a special volunteer and also has a small consulting business. Gordon M. Cragg obtained his undergraduate training in chemistry at Rhodes University, South Africa, and his DPhil (organic chemistry) from Oxford University.He has established collaborations between the NCI and organizations in many countries, promoting drug discovery from their natural resources. He has authored or coauthored over 180 papers, reviews, and book chapters. Paul G. Grothaus earned a BSChem from Creighton University in 1977 and his PhD from Purdue University in 1983, where he completed the first enantiospecific total synthesis of a trichothecene mycotoxin, anguidine.In 2007, he joined the Natural Products Branch of the National Cancer Institute in Frederick, Maryland, where he coordinates biomass collections, biological screening of extracts, and collaborations with external natural product researchers. Dr. Grothaus is the author or coauthor of 24 papers, reviews, and book chapters and holds 5 patents.